401513-90-4Relevant academic research and scientific papers
Synthesis, physicochemical properties, antimicrobial and antioxidant studies of pyrazoline derivatives bearing a pyridyl moiety
Lone, Imtiyaz Hussain,Khan, Khaliquz Zaman,Fozdar, Bharat Inder
, p. 363 - 369 (2014/03/21)
A series of new pyrazoline compounds bearing a pyridyl moiety (4a-i) were synthesized by condensing appropriate chalcones with hydrazine hydrate and tested for antimicrobial and antioxidant activities. According to in vitro antimicrobial activity against Bacillus subtilis, Staphylococcus epidermidis, Proteus vulgaris, Pseudomonas aeruginosa, Aspergillus niger and Penicillium chrysogenum and antioxidant activity by DPPH method, the compounds 4a, 4d, 4i and 4e, 4f, 4h showed maximum antimicrobial and antioxidant activities, respectively. Physiochemical properties and Lipinski's 'Rule of Five' analysis predicted higher intrinsic quality of the synthesized compounds and revealed that these compounds have good bioavailability and druglikeness properties.
Copper(ii) complexes with 3-(2-pyridyl)-4,5-dihydro-1H-pyrazoles: Synthesis, structural and electrochemical studies
Vorozhtsov, N. I.,Majouga, A. G.,Beloglazkina, E. K.,Moiseeva, A. A.,Golubeva, G. A.,Evstaf'Ev, I. V.,Sviridova, L. A.,Zyk, N. V.
, p. 657 - 661 (2015/02/02)
Three new copper(ii) complexes with the 3-(2-pyridyl)-4,5-dihydro-1H-pyrazole ligands were obtained by reactions of appropriate organic ligands with CuCl2·2H2O. The structures of the complexes were determined by X-ray diffraction. Th
Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines
Ciupa, Alexander,De Bank, Paul A.,Mahon, Mary F.,Wood, Pauline J.,Caggiano, Lorenzo
supporting information, p. 956 - 961 (2013/07/27)
The synthesis and antiproliferative activity of eleven 3-(pyrid-2-yl)- pyrazolines in two cancer cell lines are reported. X-ray crystallography was obtained of the lead compound 8i which was screened in the NCI 60 human tumour cell line and displayed sub-micromolar activity. Cell cycle analysis, in vitro tubulin assay and confocal microscopy are also reported and suggest that the lead compound disrupts microtubule formation.
Synthesis and antimycobacterial activity of 5-aryl-1-isonicotinoyl-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazole derivatives
Grazia Mamolo, Maria,Zampieri, Daniele,Falagiani, Valeria,Vio, Luciano,Banfi, Elena
, p. 593 - 599 (2007/10/03)
5-Aryl-1-isonicotinoyl-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazole derivatives were synthesized and tested for their in vitro antimycobacterial activity. The compounds showed an interesting activity against a strain of Mycobacterium tuberculosis and a human strain of M. tuberculosis H4.
