5337-53-1

Usage

Uses

Used in the Food Industry:
(E)-3-phenyl-1-(2-pyridyl)prop-2-en-1-one is used as a flavoring agent for its distinctive sweet odor, enhancing the taste and aroma of various food products.
Used in Pharmaceutical Synthesis:
(E)-3-phenyl-1-(2-pyridyl)prop-2-en-1-one serves as an intermediate in the synthesis of pharmaceuticals and other organic compounds, contributing to the development of new drugs and medications.
Used in Anti-Inflammatory and Anti-Cancer Research:
(E)-3-phenyl-1-(2-pyridyl)prop-2-en-1-one is being studied for its potential as an anti-inflammatory and anti-cancer agent, with ongoing investigations into its precise mechanism of action and potential side effects to ensure its safety and efficacy in medical applications.

Upstream product

• 110-89-4 piperidine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 536-74-3 phenylacetylene 
• 350-03-8 methyl-3-pyridylketone 
• 100-52-7 benzaldehyde 
• 1122-62-9 2-acetylpyridine 
• 98-86-2 acetophenone 

Downstream Products

• 1059698-98-4 C₂₂H₁₈N₂O 
• 1351822-57-5 6-phenyl-4-(pyridin-2-yl)-1,6-dihydropyrimidin-2-amine 
• 1351822-63-3 6-phenyl-4-(pyridin-2-yl)-1,6-dihydropyrimidine-2-thiol 
• 61453-97-2 acetic acid 3-phenyl-indolizin-1-yl ester 

Relevant academic research and scientific papers

Remarkable influence of mild Lewis acid catalysts on cycloadditions leading to tetrasubstituted isoxazolidines: DFT analysis augmented by X-ray and NMR studies

Experimental and theoretical studies were carried out to highlight the influence of mild Lewis acid catalysts on the cycloadditions leading to stereochemically defined tetrasubstituted isoxazolidines. Considerable acceleration and increased exo stereoselectivity were observed for lithium triflate and magnesium bromide catalyzed processes. DFTbased reactivity indices reflected the differences in polar character of the catalyzed and uncatalyzed pathways. The regioselectivities were predicted from interaction energy calculations. Finally, the transition states were successfully located and the extent of bond formation analyzed. The catalytic acceleration was rationalized by density functional theory (DFT) calculated activation parameters. The rate constant ratios with Eyring's transition state theory (TST) rate equation and total partition functions were also theoretically evaluated to further rationalize the observed catalytic acceleration. Springer-Verlag 2012.

Glycyrrhizic acid based self-assembled helical nanostructures as scaffolds for asymmetric Diels-Alder reaction

Glycyrrhizic acid (GA), as a traditional herbal, can self-assemble into helical nanofiber in the water. The formed helical nanostructures can be employed as scaffolds for asymmetric Diels-Alder reaction. Through co-assembling with a series of achiral copper-ligands, the chirality of GA helical nanostructures can be transferred to catalytic site, and resulted assemblies showed moderated enantioselectivity toward catalysis of Diels-Alder reaction.

Boosting the catalytic performance of zinc linked amino acid complex as an eco-friendly for synthesis of novel pyrimidines in aqueous medium

Zinc linked amino acid complex, Zn(l-proline)2, is considered as a green catalyst for the synthesis of novel series of pyrimidine derivatives 5a–q. The pyrimidines 5a–q were prepared via two pathways: the first is a one-pot reaction of guanidines 3a–c with aromatic aldehyde 1 and acetophenones 2; and the second one is the reaction of guanidines 3a–c with different chalcones 4a–j in aqueous medium. The simplicity of the operation, the short reaction time, and the high efficiency (97%) are the main advantages of this protocol. Furthermore, the green aspects of this synthetic protocol were further investigated by examining the reusability of Zn(l-proline)2 complex throughout five consecutive cycles without a significant loss of catalytic activity. This new procedure has presented remarkable advantages in terms of safety, simplicity, stability, mild conditions, a short reaction time, excellent yields, and high purities without using any organic solvents.

Modular Design of G-Quadruplex MetalloDNAzymes for Catalytic C-C Bond Formations with Switchable Enantioselectivity

Metal-binding DNA structures with catalytic function are receiving increasing interest. Although a number of metalloDNAzymes have been reported to be highly efficient, the exact coordination/position of their catalytic metal center is often unknown. Here, we present a new approach to rationally develop metalloDNAzymes for Lewis acid-catalyzed reactions such as enantioselective Michael additions. Our strategy relies on the predictable folding patterns of unimolecular DNA G-quadruplexes, combined with the concept of metal-mediated base-pairing. Transition-metal coordination environments were created in G-quadruplex loop regions, accessible by substrates. Therefore, protein-inspired imidazole ligandoside L was covalently incorporated into a series of G-rich DNA strands by solid-phase synthesis. Iterative rounds of DNA sequence design and catalytic assays allowed us to select tailored metalloDNAzymes giving high conversions and excellent enantioselectivities (≥99%). Based on their primary sequence, folding pattern, and metal coordination mode, valuable information on structure-activity relationships could be extracted. Variation of the number and position of ligand L within the sequence allowed us to control the formation of (S) and (R) enantiomeric reaction products, respectively.

Design, Synthesis, and Evaluation of Chalcone Derivatives as Multifunctional Agents against Alzheimer's Disease

Fifteen chalcone derivatives 3a–3o were synthesized, and evaluated as multifunctional agents against Alzheimer's disease. In vitro studies revealed that these compounds inhibited self-induced Aβ1-42 aggregation effectively ranged from 45.9–94.5

Chiral bipyridine-annulated bicyclo[3.3.1]nonane N-oxide organocatalysts for stereoselective allylation and hydrosilylation reactions

The synthesis of chiral C2-symmetric bis(bipyridine N,N′-dioxide) and bis(bipyridine N-monooxide) derivatives featuring bipyridine-annulated bicyclo[3.3.1]nonane framework is reported. The new Lewis basic bipyridine N,N′-dioxides exhibited good

Light-Driven Enantioselective Synthesis of Pyrroline Derivatives by a Radical/Polar Cascade Reaction

Herein, a light-driven, atom-economical process that provides access to enantiomerically enriched substituted chiral 1-pyrroline derivatives is introduced. The strategy involves the distal functionalization of acyl heterocycles through a hydrogen-atom transfer (HAT) process and the use of tailor-made ketimines as reliable electrophilic partners. This transformation is translated into an enantiomerically controlled radical/polar cascade reaction in which water is produced as the sole by-product and stereoselectivity is dictated by coordination to a chiral-at-rhodium catalyst.

Synthesis and Luminescence Spectral Properties of New Cyano-Substituted 2,2′-Bipyridine Derivatives

Abstract: Previously unknown 2-{4-aryl-5-cyano-[2,2′-bipyridin]-6(1H)-ylidene}malononitriles were synthe-sized by reaction of 3-aryl-1-(pyridin-2-yl)prop-2-en-1-ones (azachalcones) with malononitrile dimer. Their colored solutions showed fluorescence in t

Fabrication of Copper-based Silica-coated Magnetic Nanocatalyst for Efficient One-pot Synthesis of Chalcones via A3 Coupling of Aldehydes-Alkynes-Amines

In the present work, we have synthesized bioactive and pharmacologically important chalcone motifs by employing green and efficient silica-coated magnetically separable catalyst, Cu@DBM@ASMNPs. The highly proficient nanocatalyst proves its invincibility f

Pincerlike polypyridine-polypyrrole silver cluster compound containing five coordination sites, and preparation method and application thereof

The invention discloses a pincerlike polypyridine-polypyrrole silver cluster compound containing five coordination sites. The molecular formula of the pincerlike polypyridine-polypyrrole silver cluster compound is [Ag4(C35N5H23)2], wherein C35N5H23 is a pincerlike polypyridine-polypyrrole ligand containing five coordination sites, and the pincerlike polypyridine-polypyrrole ligand is 5,5'-(pyridine-2,6-methylene)bis(4-phenyl-2-(2-pyridyl)-1-pyrrole anion). The invention further discloses a preparation method of the pincerlike polypyridine-polypyrrole silver cluster compound containing the fivecoordination sites. The preparation method has the advantages of simplicity in reaction operation, easiness in implementation, high reaction yield, high purity of the obtained product, and good repeatability. The pincerlike polypyridine-polypyrrole silver cluster compound containing the five coordination sites belongs to a novel triboluminescence material, is a novel blue luminescent material, and can be applied to an organic blue luminescent material.