40155-43-9 Usage
Uses
Used in Pharmaceutical Synthesis:
5-AMINO-PYRAZINE-2-CARBOXYLIC ACID is used as a key intermediate in the synthesis of pharmaceuticals for its ability to form diverse chemical structures and functional groups, enhancing the development of new drugs with improved therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 5-AMINO-PYRAZINE-2-CARBOXYLIC ACID is utilized as a building block for the creation of novel agrochemicals, such as pesticides and herbicides, due to its potential to improve the efficacy and selectivity of these compounds.
Used in Organic Compounds Synthesis:
5-AMINO-PYRAZINE-2-CARBOXYLIC ACID serves as a versatile precursor in the synthesis of various organic compounds, including dyes, polymers, and other specialty chemicals, owing to its reactive functional groups and compatibility with a wide range of chemical reactions.
Used in Antioxidant Applications:
5-AMINO-PYRAZINE-2-CARBOXYLIC ACID is studied for its potential as an antioxidant, which could be beneficial in protecting cells from oxidative stress and related diseases, as well as in stabilizing sensitive compounds in various industrial applications.
Used in Cancer Treatment Research:
5-AMINO-PYRAZINE-2-CARBOXYLIC ACID has been investigated for its potential therapeutic uses in cancer treatment, with research exploring its ability to target cancer cells and modulate signaling pathways, offering a promising avenue for the development of novel anticancer agents.
Used in Neurodegenerative Disease Research:
In the field of neurodegenerative diseases, 5-AMINO-PYRAZINE-2-CARBOXYLIC ACID is being studied for its potential to mitigate the effects of these conditions, possibly through its antioxidant properties or other mechanisms that protect neurons and slow disease progression.
Check Digit Verification of cas no
The CAS Registry Mumber 40155-43-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,1,5 and 5 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 40155-43:
(7*4)+(6*0)+(5*1)+(4*5)+(3*5)+(2*4)+(1*3)=79
79 % 10 = 9
So 40155-43-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H5N3O2/c6-4-2-7-3(1-8-4)5(9)10/h1-2H,(H2,6,8)(H,9,10)
40155-43-9Relevant academic research and scientific papers
Ureidopyrazine derivatives: Synthesis and biological evaluation as Anti-infectives and abiotic elicitors
Bouz, Ghada,Juhás, Martin,Niklová, Pavlína,Jand’ourek, Ond?ej,Paterová, Pavla,Ek, Ji?í Janou,T?mová, Lenka,Kovalíková, Zuzana,Kastner, Petr,Dole al, Martin,Zitko, Jan
, (2017/11/14)
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) has become a frequently deadly infection due to increasing antimicrobial resistance. This serious issue has driven efforts worldwide to discover new drugs effective against Mtb. One research area is the synthesis and evaluation of pyrazinamide derivatives as potential anti-TB drugs. In this paper we report the synthesis and biological evaluations of a series of ureidopyrazines. Compounds were synthesized by reacting alkyl/aryl isocyanates with aminopyrazine or with propyl 5-aminopyrazine-2-carboxylate. Reactions were performed in pressurized vials using a CEM Discover microwave reactor with a focused field. Purity and chemical structures of products were assessed, and the final compounds were tested in vitro for their antimycobacterial, antibacterial, and antifungal activities. Propyl 5-(3-phenylureido)pyrazine-2-carboxylate (compound 4, MICMtb = 1.56 μg/mL, 5.19 μM) and propyl 5-(3-(4-methoxyphenyl)ureido)pyrazine-2-carboxylate (compound 6, MICMtb = 6.25 μg/mL, 18.91 μM) had high antimycobacterial activity against Mtb H37Rv with no in vitro cytotoxicity on HepG2 cell line. Therefore 4 and 6 are suitable for further structural modifications that might improve their biological activity and physicochemical properties. Based on the structural similarity to 1-(2-chloropyridin-4-yl)-3-phenylurea, a known plant growth regulator, two selected compounds were evaluated for similar activity as abiotic elicitors.
