40160-26-7 Usage
Description
1-[2-(Trifluoromethyl)phenyl]piperazinium chloride is a chemical compound that belongs to the class of piperazinium salts. It is characterized by the presence of a trifluoromethyl group attached to a phenyl ring, which is connected to a piperazine moiety. 1-[2-(trifluoromethyl)phenyl]piperazinium chloride is often used as a reference standard and is related to Piperazine, an anthelmintic agent.
Uses
Used in Pharmaceutical Industry:
1-[2-(Trifluoromethyl)phenyl]piperazinium chloride is used as a reference standard for the development and validation of analytical methods in the pharmaceutical industry. Its role as a reference standard helps ensure the accuracy and reliability of tests and measurements related to the synthesis, quality control, and pharmacological evaluation of Piperazine and its derivatives.
Used in Anthelmintic Applications:
As a related compound of Piperazine, an established anthelmintic, 1-[2-(Trifluoromethyl)phenyl]piperazinium chloride may potentially be used for the development of new anthelmintic agents. Its unique chemical structure could offer novel therapeutic properties and contribute to the treatment of parasitic worm infections.
Used in Research and Development:
1-[2-(Trifluoromethyl)phenyl]piperazinium chloride is also utilized in research and development for the synthesis and study of new chemical entities with potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science. Its unique structure and properties make it a valuable tool for exploring new avenues in chemical and biological research.
Check Digit Verification of cas no
The CAS Registry Mumber 40160-26-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,1,6 and 0 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 40160-26:
(7*4)+(6*0)+(5*1)+(4*6)+(3*0)+(2*2)+(1*6)=67
67 % 10 = 7
So 40160-26-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H13F3N2.ClH/c12-11(13,14)9-3-1-2-4-10(9)16-7-5-15-6-8-16;/h1-4,15H,5-8H2;1H
40160-26-7Relevant articles and documents
Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease
Cioffi, Christopher L.,Racz, Boglarka,Freeman, Emily E.,Conlon, Michael P.,Chen, Ping,Stafford, Douglas G.,Schwarz, Daniel M.C.,Zhu, Lei,Kitchen, Douglas B.,Barnes, Keith D.,Dobri, Nicoleta,Michelotti, Enrique,Cywin, Charles L.,Martin, William H.,Pearson, Paul G.,Johnson, Graham,Petrukhin, Konstantin
, p. 5863 - 5888 (2015)
Antagonists of retinol-binding protein 4 (RBP4) impede ocular uptake of serum all-trans retinol (1) and have been shown to reduce cytotoxic bisretinoid formation in the retinal pigment epithelium (RPE), which is associated with the pathogenesis of both dry age-related macular degeneration (AMD) and Stargardt disease. Thus, these agents show promise as a potential pharmacotherapy by which to stem further neurodegeneration and concomitant vision loss associated with geographic atrophy of the macula. We previously disclosed the discovery of a novel series of nonretinoid RBP4 antagonists, represented by bicyclic [3.3.0]-octahydrocyclopenta[c]pyrrolo analogue 4. We describe herein the utilization of a pyrimidine-4-carboxylic acid fragment as a suitable isostere for the anthranilic acid appendage of 4, which led to the discovery of standout antagonist 33. Analogue 33 possesses exquisite in vitro RBP4 binding affinity and favorable drug-like characteristics and was found to reduce circulating plasma RBP4 levels in vivo in a robust manner (>90%).
