401643-95-6Relevant academic research and scientific papers
An efficient and green synthesis of 6-amino-3-phenyl-4-aryl-1,4- dihydropyrano [2,3-c]pyrazole-5-carbonitrile derivatives under ultrasound irradiation in aqueous medium
Zou, Yi,Hu, Yu,Liu, Hai,Shi, Da-Qing
, p. 1174 - 1179 (2013/10/21)
A facile and eco-friendly approach for the synthesis of 6-amino-3-phenyl-4-aryl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile derivatives via four-component reaction of hydrazine, ethyl 3-oxo-3- phenylpropanoate, aldehydes, and malononitrile is described. The reaction is performed in water, without using any catalyst, and under ultrasound irradiation. The developed sonochemical-assisted multi-component reaction provides an improved and accelerated conversion when compared with conventional procedure.
Pyrazolones as building blocks in heterocyclic synthesis: Synthesis of new pyrazolopyran, pyrazolopyridazine and pyrazole derivatives of expected antifungicidal activity
Ramiz, Mahmoud M. M.,Abdel Hafiz, Ibrahim S.,Abdel Reheim, Mohamed A. M.,Gaber, Hatem M.
experimental part, p. 72 - 80 (2012/06/30)
A series of new pyrazolone and pyrazole derivatives with expected antifungicidal activity have been prepared through the reactions 3-phenyl-1-H-pyrazol-5(4H)-one (3) and 4-(dimethylaminomethylene)-3-phenyl-1H- pyrazol-5(4H)-one (5) with a variety of electrophilic reagents and nucleophilic reagents. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral studies.
