401894-77-7Relevant academic research and scientific papers
Synthesis of Lower rim polyhydroxylated calix[4]arenes
Segura,Sansone,Casnati,Ungaro
, p. 2105 - 2112 (2007/10/03)
Several synthetic procedures were evaluated and a protective/deprotective method, which allows the introduction of two, three, and four amide-linked polyhydroxylated units (TRIS) at the lower rim of calix[4]arenes was developed. Di- and trifunctionalized derivatives are poorly soluble in water, whereas the solubility of calix[4]arene having four polyhydroxylated amide groups is good (6 × 10-3 M at 25 °C).
