40206-02-8

Upstream product

• 124-41-4 sodium methylate 
• 3095-73-6 1,2,3,4,5,6-hexa(bromomethyl)benzene 
• 16356-02-8 1,4-dimethoxy-2-butyne 
• 612-12-4 o-Xylylene dichloride 
• 124-38-9 carbon dioxide 

Relevant academic research and scientific papers

Cobalt-Catalyzed Formal [4+2] Cycloaddition of α,α′-Dichloro-ortho-Xylenes with Alkynes

A formal [4+2] cycloaddition of α,α′-dichloro-ortho-xylenes with various alkynes has been developed using a low-valent cobalt catalyst. The transformation has a wide substrate scope and high functional-group tolerance and led to 1,4-dihydronaphthalenes. T

Solvent-free synthesis of 2-pyrones from alkynes and carbon dioxide catalyzed by Ni(1,5-cyclooctadiene)2/trialkylphosphine catalysts

Solvent-free, efficient, and mild 2-pyrone synthesis by the cycloaddition of alkynes with CO2 has been achieved under compressed CO2 with a Ni(cod)2/P(C4H9)3 or Ni(cod)2/P(C8H17)3 catalyst; both high yields (up to 98%) and selectivities (up to 99%) are attained. One attractive aspect of these catalysts is their high efficiency at low CO 2 pressures (4 MPa). The applicability of this reaction to a broad range of alkyne substrates and the ease of handling the phosphine ligands are additional merits of the present new catalytic systems in comparison to the previously reported Ni(cod)2/P(CH3)3 catalyst in supercritical CO2. Georg Thieme Verlag Stuttgart.

Cobalt Octacarbonyl-Catalyzed Scalable Alkyne Cyclotrimerization and Crossed [2 + 2 + 2]-Cycloaddition Reaction in a Plug Flow Reactor

Cobalt-catalyzed alkyne cyclotrimerization and crossed [2 + 2 + 2] cycloadditions are developed in a plug flow reactor. The protocol generally uses 5 mol % of Co2(CO)8 and is scalable at least at multigram scale. Efficient and scalable use of Co2(CO)8 for crossed reactions of diynes and alkynes has hardly any precedent.

Cyclotrimerisation catalytique d'alcynes par des complexes du nickel formes ''in situ''

Catalytic cyclotrimerization of acetylenic compounds by transient complexes formed in the reduction of nickel halides by magnesium, occurs with many alkynes; however, this cyclization is hindered when bulky groups are close neighbors of the triple bond or when acceptor groups are in the α position with respect to the unsaturated carbon.On the other hand, the yield of trimer increases to become quantitative with releasing substituents.

Zusammenhaenge zwischen Alkinkomplexierung und-Aktivierung in Komplexen des Types (Ligand)2Ni(Alkin)

In the well defined new Ni0 complexes (ligand)2Ni(acetylene) the different methods of complexation of acetylenes is influenced by the electronic properties of ligands and acetylene substituents, as interpreted from their infrared spectra.So, in the case of acceptor acetylenes the best complexation with a donor ligand (and vice-versa) was found.The degree of complexation is proportional to the activation of the complexed acetylene and is illustrated by a number of reactions, which are different for acceptor and donor ligands.Cyclooligomerization of acetylenes is the most interesting example because strong donor ligands in complex catalysts affect the system in such a way we obtained excellent catalysts with turnover numbers of more than 1000000 moles of acetylene per mole of catalyst.Such catalysts are as yet unknown in acetylene chemistry and very rare in other C-C coupling reactions.

Preparation and Properties of Hexasubstituted Benzenes

Hexasubstituted benzenes are of potential interests as polypodands, host molecules and disc-like molecules.They are prepared by catalytic cyclotrimerization of disubstituted alkynes 1-8 or by nucleophilic substitution of bromine in hexakis (bromomethyl)be