40224-22-4

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-nitrobenzyl)-4-phenylpiperazine is used as a key intermediate for the synthesis of ropinirole, a dopamine agonist, for the treatment of neurological disorders such as Parkinson's disease and restless legs syndrome. The presence of the 4-nitrobenzyl group in the molecule allows for the introduction of additional functional groups to the piperazine ring, which is crucial for the development of ropinirole's therapeutic properties.
Used in the Synthesis of Dopamine Agonists:
1-(4-nitrobenzyl)-4-phenylpiperazine is used as a precursor in the production of dopamine agonists, specifically ropinirole. Its role in the synthesis process is to provide the necessary structural components for the formation of the final drug, which can then be used to alleviate symptoms associated with Parkinson's disease and restless legs syndrome.
Used in the Development of Neurological Medications:
1-(4-nitrobenzyl)-4-phenylpiperazine is used as a crucial building block in the development of medications targeting neurological disorders. Its importance lies in its ability to contribute to the synthesis of ropinirole, a drug that has proven effective in managing the symptoms of Parkinson's disease and restless legs syndrome, thus improving the quality of life for patients suffering from these conditions.

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 100-14-1 4-nitrobenzyl chloride 
• 2210-93-7 N-phenylpiperazine hydrochloride 

Downstream Products

• 40224-23-5 1-phenyl-4-[(4-aminophenyl)methyl]piperazine 
• 394203-81-7 1-(4-phenylpiperazine-1-yl-methyl)phenylacetamide 
• 394203-84-0 4-(4-phenyl-piperazin-1-ylmethyl)-benzene-1,2-diamine 
• 394203-83-9 2-nitro-4-(4-phenylpiperazin-1-yl-methyl)phenylamine 
• 394203-82-8 N-[4-(4-phenylpiperazinyl-1-methyl)-2-nitrophenyl]acetamide 

Relevant academic research and scientific papers

Development of a potent and selective FLT3 kinase inhibitor by systematic expansion of a non-selective fragment-screening hit

A non-selective inhibitor (1) of FMS-like tyrosine kinase-3 (FLT3) was identified by fragment screening and systematically modified to afford a potent and selective inhibitor 26. We confirmed that 26 inhibited the growth of FLT-3-activated human acute myeloid leukemia cell line MV4-11. Our design strategy enabled rapid development of a novel type of FLT3 inhibitor from the hit fragment in the absence of target-structural information.

ARYLALKYLPIPERAZINES FOR USE AS NEUROPROTECTIVE AGENTS

A compound of the general formula A or a or a pharmaceutically acceptable salt or solvate thereof, wherein: R1 is selected from the group consisting of: C1-C12-alkyl, C3-C12-cycloalkyl, C6-

Click chemistry on solid support: Synthesis of a new REM resin and application for the preparation of tertiary amines

1,3-Dipolar cycloaddition was employed for the synthesis of a highly practical REM resin. Exploiting this concept, the resulting triazolylmethyl acrylate (TMA) resin was used for an efficient parallel synthesis of tertiary amines by Michael addition, subs

Substituted indolines which inhibit receptor tyrosine kinases

Indolinones of the formula having an inhibitory effect on receptor tyrosine kinases and cyclin/CDK complexes, as well as on the proliferation of endothelial cells and various tumor cells. Exemplary are: (a) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-ethoxycarbonyl-2-indolinone, (b) 3-Z-[(1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-carbamoyl-2-indolinone, and (c) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-metboxycarbonyl-2-indolinone.

Solid phase supports

Embodiments of the present invention generally relate to carrying out organic chemistry on solid supports comprising derivatised functionalities, methods for synthesizing said supports, methods for synthesizing compounds comprising amine groups or N-containing heterocycles using said solid supports, intermediate compounds linked to said supports and uses thereof.

Investigation of mixed D2/5-HT1A activity of N-heteroarylmethyl-N-phenylpiperazines, N-heteroarylethyl-N-phenylpiperazines and N-heteroarylpropyl-N-phenylpiperazines.

Eight novel N-heteroarylalkyl-N-phenylpiperazines have been synthesized, chemically characterized and evaluated for in vitro binding affinity at the dopamine and serotonin receptors. Synaptosomal membranes of fresh bovine caudate nuclei (D1 and D2), the m

Substituted indolinones with kinase inhibitory activity

Substituted indolinones of general formula having effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells. Exemplary compounds are: 3-Z-[1-(4-(N-Benzyl-N-methyl-aminomethyl)-phenylamino)-1-methyl-methylene]-5-a

Soluble polymer bound cleavage reagents: A multipolymer strategy for the cleavage of tertiary amines from REM resin

(equation presented) Soluble polymer bound reagent 1 has been prepared to cleave tertiary amines from REM resin. Normally, amines cleaved from REM resin require extraction or chromatography to remove excess cleavage reagent and its byproducts. The solubility profile of non-crosslinked polystyrene (NCPS) based reagent 1 eliminates the need for such purification and allows for the direct isolation of a library of pure tertiary amines through simple filtration and concentration operations.

Synthesis of tertiary amines using a polystyrene (REM) resin

A range of tertiary amines was constructed using a 'traceless' linker on a polystyrene resin (REM resin), starting from seconday amines, primary amines, and resin-bound 'ammonia'. The methodology is characterized by three essential steps conducted under ambient conditions: (1) coupling of the starting amine (Michael addition) to the resin, (2) activation (quaternization), and (3) cleavage of the product amine (Hofmann elimination). The linker is compatible with both acid and base sensitive protecting group strategies. The nature of the chemistry ensures that the tertiary amine products are obtained in consistently high purity (95% or greater). After cleavage of the product, REM resin is regenerated and can be reused for repeat syntheses. The yield and purity of repeat batches is maintained over 5 cycles, allowing the automated synthesis of >0.5 g quantities of pure tertiary amine.

Piperazino methyl phenyl aminoquinolines

Antihypertensive compounds of the formula III STR1 wherein X is chloro or trifluoromethyl; wherein R is hydrogen or alkyl of 1 to 3 carbon atoms, inclusive; wherein R1 is phenyl or phenyl substituted with one or two alkyl, alkoxy, trifluorometh