40231-75-2

Basic information

• Product Name: Benzene, 1,1'-(2-bromoethylidene)bis-
• CAS NO: 40231-75-2
• Molecular Formula: C14H13Br
• Molecular Weight: 261.161
• Mol File: 40231-75-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzene, 1,1'-(2-bromoethylidene)bis-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,1'-(2-bromoethylidene)bis-(40231-75-2)
• EPA Substance Registry System: Benzene, 1,1'-(2-bromoethylidene)bis-(40231-75-2)

Safety Data

• Hazardous Substances Data: 40231-75-2(Hazardous Substances Data)

Upstream product

• 1883-32-5 2,2-diphenyl ethanol 
• 119-61-9 benzophenone 
• 557-68-6 iodobromomethane 
• 530-48-3 1,1-Diphenylethylene 

Downstream Products

• 530-48-3 1,1-Diphenylethylene 
• 1883-32-5 2,2-diphenyl ethanol 
• 1443367-77-8 3,3-diphenyl-1-(4-(trifluoromethyl)phenyl)propan-1-one oxime 
• 1443367-53-0 5,5-diphenyl-3-(4-(trifluoromethyl)phenyl)-4,5-dihydroisoxazole 
• 1443368-19-1 3,3-diphenyl-1-(4-(trifluoromethyl)phenyl)propan-1-one 
• 71351-02-5 1,1-diphenylethanethiol 
• 863911-60-8 {3-[3-(2,2-diphenylethylsulfanyl)propyl]benzofuran-7-yloxy}acetic acid methyl ester 
• 863911-57-3 {3-[2-(2,2-diphenylethylsulfanyl)ethyl]benzofuran-7-yloxy}acetic acid methyl ester 
• 863911-55-1 [3-(2,2-diphenylethylsulfanylmethyl)benzofuran-7-yloxy]acetic acid methyl ester 
• 863911-53-9 3-(2,2-diphenylethylsulfanylmethyl)benzofuran-7-ol 
• 863911-51-7 3-(2,2-diphenylethylsulfanylmethyl)-7-methoxybenzofuran 
• 863911-83-5 di-(2,2-diphenylethyl) disulfide 
• 863911-82-4 2-(2,2-diphenylethylsulfanyl)benzoxazole 
• 81113-23-7 diethyl 3,3-diphenylpropane-1,1-dicarboxylate 

Relevant articles and documents

An Electron Spin Resonance Investigation of β-Substituted 1,1-Diphenylethyl Radicals

A large number of β-substituted 1,1-diphenylethyl derivatives Ph2C.CH2MRn have been generated by addition of .MRn radicals to 1,1-diphenylethylene.The magnitude of the β-proton hyperfine splitting constants toge

Development of dual-acting benzofurans for thromboxane A2 receptor antagonist and prostacyclin receptor agonist: Synthesis, structure-activity relationship, and evaluation of benzofuran derivatives

Prostacyclin (PGI2) is an unstable, powerful endogenous inhibitor of platelet aggregation, and thromboxane A2 (TXA 2) is an unstable endogenous arachidonic acid metabolite that plays a pivotal role in platelet aggregation and vasoconstriction. The balance between TXA2 and PGI2 greatly affects maintenance of the homeostasis of the circulatory system. A novel series of benzofuran-7- yloxyacetic acid derivatives was discovered as potent dual-acting agents to block the thromboxane A2 receptor and to activate the prostacyclin receptor. Synthesis, structure-activity relationship, and in vitro and ex vivo pharmacology of this series of compounds are described. The most potent in the series was {3-[2-(1,1-diphenylethylsulfanyl)ethyl]-2-hydroxymethylbenzofuran-7- yloxy}acetic acid diethanolamine salt (7) with Ki of 4.5 nM for thromboxane receptor antagonism and Ki of 530 nM for prostacyclin receptor agonism. Remarkably, compound 7 is a promising candidate for novel treatment as an antithrombotic agent with other cardiovascular actions to avoid hypotensive side effects.