81113-23-7Relevant academic research and scientific papers
Development of Br?nsted Base-Photocatalyst Hybrid Systems for Highly Efficient C-C Bond Formation Reactions of Malonates with Styrenes
Ba?, Sebastian,Kobayashi, Shū,Yamashita, Yasuhiro
, p. 10546 - 10550 (2020/11/09)
Br?nsted base-photocatalyst hybrid systems have been developed for reactions of malonates with styrene derivatives. The concept of this process lies in the photo-oxidation of catalytic amounts of the enolate to form reactive radicals that react with alken
N-, α-, and β-substituted 3-aminopropionic acids: Design, syntheses and antiseizure activities
Tan,Wainman,Weaver
, p. 113 - 121 (2007/10/03)
A treatment for epilepsy is proposed based on analogues of 3-aminopropionic acid (β-alanine), a putative neurotransmitter in the central nervous system (CNS). A model three point pharmacophore was proposed based on modelling data obtained from the study of antagonists for both the glial γ-aminobutyric acid (GABA)-uptake site and the glycine co-agonist site of N-methyl-D-aspartate (NMDA) receptor. Three series of 3-aminopropionic acids containing, N-, α-, and β-substituents, were designed and synthesized to probe the position and the size of a lipophilic binding pocket within the proposed pharmacophore. These analogues were tested in vivo for both their antiseizure activities and their neurologic toxicities. Among the fourteen novel 3-aminopropionic acids synthesized, eight were found to have promising antiseizure activity. This study shows that substitution on the N-terminus confers the greatest antiseizure activity, particularly against pilocarpine-induced seizures.
Photochemical Addition of Tertiary Amines to Electrophilic Cyclopropranes via Single Electron Transfer
Tomioka, Hideo,Miyagawa, Hiroshi
, p. 1183 - 1184 (2007/10/02)
Irradiation of arylcyclopropanes bearing at least one electron-withdrawing group with a tertiary amine in acetonitrile resulted in the formation of the regioselective addition product of the amine along with the reduction product.
Reaction with Umpolung of the Malonyl Radical
Giese, Bernd,Horler, Hans,Leising, Michael
, p. 444 - 452 (2007/10/02)
The malonyl radical 3 can be generated from chloro- or bromomalonate in a radical chain reaction.This radical reacts with enol ethers 6 to addition products 7 or substitution products 10.During the formation of 7 the adduct radicals 12 are trapped by tin
The Mechanisms of Decomposition of the 1- and 2-Phenyltetralin Radical Cations
Gallagher, James J.,Chess, Edward K.,Arghestani Saleh M.,Gross, Michael L.
, p. 118 - 126 (2007/10/02)
Mechanisms for decomposition of 1- and 2-phenyltetralins were investigated using low resolution mass spectrometry and metastable ion tecniques.Four primary decompositions were observed for 1-phenyltetralin radical cations: (1) the loss of C6H6 via a 1,4-elimination; (2) the elimination of ethene via competing losses from carbons 3+4 and carbons 2+3; (3) the loss of C8H8, probably through a stepwise Diels-Alder cycloreversion to expel styrene; and (4) the loss of methyl radical involving carbon 2 and possible carbon 4.Three major decompositions were observed for 2-phenyltetralin radical cations: (1) the loss of C8H8, possible through a Diels-Alder cycloreversion to expel styrene; (2) the loss of C6H6 via a 1,3 elimination; and (3) the loss of methyl radical from carbon 1.Various exchange reactions occur prior to these losses, but they proved to be incomplete even for metastable ions.
α-Naphthol Synthesis via Knoevenagel Condensation in the Presence of Molecular Sieves
Taylor, Giles A.
, p. 3132 - 3134 (2007/10/02)
Diphenylethanal condenses with diethyl malonate, ethyl acetoacetate, and ethyl benzoylacetate under Knoevenagel conditions in the presence of molecular sieves to give the 1-naphthols (2), (5), and (6).Glass wool is a less effective catalyst for formation of (2). 3,3-Diethoxycarbonyl-1,1-diphenylpropene (4) is converted into the naphthol (2) in high yield by heating with molecular sieves but its saturated analogue (3) is unaffected.
