40232-99-3Relevant articles and documents
γ-Radiolysis of 1-Substituted 5-Fluorouracil Derivatives
Kuroda, Tokuyuki,Hisamura, Koji,Matsukuma, Ikuo,Nishikawa, Hiroshi,Nakamizo, Nobuhiro
, p. 674 - 681 (2007/10/02)
A new concept, "Radiation-Induced Drug (RID)", was proposed as a novel type of drugs for cancer therapy.To test the usefulness of this concept, 5-fluorouracil (5-FU) derivatives having various types of substituents at the 1-position were prepared and the γ-radiolyses of their aqueous solutions were studied.The compounds having sulfonyl and thioureido groups as the substituents produced efficiently 5-FU with high G valus upon γ-irradiation.The medium effects on the radiolyses revealed that the above two substituents were removed mainly with HO. and hydrated electrons e-eq.