40235-08-3Relevant academic research and scientific papers
7-Methyl-1-isopropyl-4-phenyl-5,6,7,8-tetrahydro-2(1H)-quinazolinone
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, (2008/06/13)
Compounds of the formula I: SPC1 wherein R° is lower alkyl, n is 0, 1 or 2, R is lower alkyl, R' is a radical of the formula SPC2 In which Y and Y' are the same or different and represent hydrogen, lower alkyl, lower alkoxy, halo of atomic weight of 19 to 36 or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a radical of the formula SPC3 In which Y" is hydrogen, fluorine, chlorine or alkyl of 1 to 3 carbon atoms, Are prepared by cyclizing a compound of formula II SPC4 in which R, R', R° and n are as defined above, with phosgene, or, Where R is not a tertiary alkyl group in which the tertiary carbon atom is directly attached to the ring nitrogen atom, with a C1 -C2 alkyl chlorocarbonate or 1,1'carbonyldiimidazole. The compounds of formula I possess pharmaceutical activity in animals.
