40239-75-6

Basic information

• Product Name: 1-nitroacridin-9(10H)-one
• CAS NO: 40239-75-6
• Molecular Formula: C₁₃H₈N₂O₃
• Molecular Weight: 240.2142
• Mol File: 40239-75-6.mol

Chemical Properties

• Boiling Point: 430.9°C at 760 mmHg
• Flash Point: 214.4°C
• Density: 1.409g/cm³
• Vapor Pressure: 1.25E-07mmHg at 25°C
• Refractive Index: 1.672
• CAS DataBase Reference: 1-nitroacridin-9(10H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-nitroacridin-9(10H)-one(40239-75-6)
• EPA Substance Registry System: 1-nitroacridin-9(10H)-one(40239-75-6)

Safety Data

• Hazardous Substances Data: 40239-75-6(Hazardous Substances Data)

Usage

Chemical Family

Acridine
1-nitroacridin-9(10H)-one belongs to the acridine family of compounds.

Derivative

Acridine with a nitro group
It is a derivative of acridine, with a nitro group attached to the 1-position of the molecule.

Potential Applications

Pharmaceuticals, dyes, and pesticides
The compound has potential applications in various fields, including pharmaceuticals, dyes, and pesticides.
4. Cytotoxic and Antitumor Properties
1-nitroacridin-9(10H)-one is known for its cytotoxic and antitumor properties, making it a potential candidate for anticancer drug development.
5. Fluorescent Properties
The compound exhibits fluorescent properties, which makes it useful in the field of fluorescence microscopy and organic light-emitting diodes.
6. Health and Environmental Risks
Despite its potential benefits, 1-nitroacridin-9(10H)-one poses health and environmental risks and should be handled with caution.

Upstream product

• 30904-48-4 1-Nitroacridine 
• 27693-70-5 N-(3-nitrophenyl)anthranilic acid 
• 63926-85-2 6-amino-1-nitroacridone 
• 86602-06-4 2-(1-Nitro-acridin-9-ylamino)-propionic acid ethyl ester 
• 99-09-2 3-nitro-aniline 
• 88-65-3 2-bromobenzoic-acid 
• 260-94-6 acridine 
• 687978-73-0 6-acetylamino-1-nitro-9-(3-dimethylaminopropylamino)-acridine 
• 86026-78-0 6-acetylamino-1-nitro-9-pyridinium chloride 
• 86026-76-8 potassium 2-bromo-4-acetylaminobenzoate 
• 86026-75-7 N(3'-nitrophenyl)-4-acetylaminoanthranilic acid 
• 86602-11-1 N(1-nitroacridyl-9)-DL-asparagine 
• 86602-09-7 3-Hydroxy-2-(1-nitro-acridin-9-ylamino)-butyric acid ethyl ester 
• 86602-07-5 3-Methylsulfanyl-2-(1-nitro-acridin-9-ylamino)-propionic acid ethyl ester 

Downstream Products

• 578-06-3 acridin-1-ylamine 
• 17431-90-2 1-nitro-9-chloroacridine 
• 7251-00-5 2-nitroacridone 
• 776299-26-4 1-(p-acetylaminobenzenesulphonylamino)-acridone 
• 676456-12-5 1-(p-aminobenzenesulphonylamino)acridone 
• 66073-40-3 1-aminoacridin-9(10H)-one 
• 72567-64-7 1-amino-2,4-dipiperidinoacridone 
• 65782-80-1 1-hydroxylamino-9-acridone 

Relevant articles and documents

Potent acetylcholinesterase inhibitors: Synthesis, biological assay and docking study of nitro acridone derivatives

The reaction of o-halobenzoic acid with aniline derivatives and their subsequent cyclization reaction yielded the acridone derivatives. The series of nitro acridone derivatives were prepared by Ullmann condensation in presence of copper as catalyst and we

Substituent Effects on the Hydrolysis of Analogues of Nitracrine -1-nitroacridine>

Studies of the hydrolysis of the hypoxia-selective cytotoxic agent 9--1-nitroacridine (nitracrine) and several of its 4-substituted analogues and nitro-positional isomers have been carried out.Examination of the effects of pH and temperature on the hydrolysis of nitracrine itself shows that the reaction is subject to acid catalysis.The value of ΔH(excit.) increases from 46 to 63 kJ mol-1 as the pH falls from 6 to 3, while the value of ΔS(excit.) increases from -195 to -138 J k-1 mol-1.The rate constants for hydrolysis and the acid dissociation constants have been measured at pH 5 and 60 deg C.Both the rate constants of hydrolysis, corrected for the substrate-protonation equilibrium, and the substrate-acid association constants are well fitted by the Ehrenson-Brownlee-Taft dual-substituent-parameter ?R- relationship.The Swain-Unger-Rosenquist-Swain relationship shows weak correlation but the linear free-energy relationships of Hammett and Yukawa-Tsuno are not fitted.The results are discussed in terms of the resonance interactions of the possible intermediates in the hydrolysis pathways.

REACTIONS AT C9 OF ACRIDINE DERIVATIVES. PART XXVII. KINETICS OF HYDROLYSIS OF N(1-NITROACRIDYL-9)-DL-AMINO ACIDS

The spectrophotometric method has been used in hydrolytic investigation of seven N(1-nitroacridyl-9)-DL-amino acids.Influence of pH on hydrolysis rate and kinetic isotope effect have been examined.Rate constants and activation parameters have been given and reaction mechanism discussed.