40240-66-2Relevant academic research and scientific papers
Base- and metal-free decarboxylative aldol reaction of β-ketoacids with glyoxylate hydrates and glyoxal monohydrates in water
Ren, Nan,Nie, Jing,Ma, Jun-An
, p. 6609 - 6617 (2018/06/08)
An environmentally benign decarboxylative aldol reaction of β-ketoacids with glyoxylate and glyoxal monohydrates in water is reported. The reaction proceeds smoothly without any base and metal catalysts, affording the corresponding β-hydroxy ketones in high yields. A preliminary mechanism study of this aldol transformation suggests a stepwise process involving the nucleophilic addition of β-ketoacids to glyoxylate hydrates and glyoxal monohydrates followed by a subsequent decarboxylation reaction.
DABCO-catalyzed green synthesis of 2-Hydroxy-1,4-diones via direct aldol reaction of arylglyoxals in water
Saraei, Mahnaz,Eftekhari-Sis, Bagher,Mozaffarnia, Sakineh
, p. 252 - 259 (2013/07/26)
A green and simple method to synthesize of 1,4-diketones via aldol reaction of arylglyoxals and ketones such as 1-(4-methoxyphenyl)-2-propanone, deoxybenzoin and substituted acetophenones in the presence of a catalytic amount of DABCO in water at room temperature has been reported. Corresponding 2-hydroxy-1,4-diones were obtained in moderate to high yields with simple separation of obtained solid from reaction mixture and recrystallization.
