40241-78-9

Basic information

• Product Name: 2-(METHYLTHIO)-4,5-DIHYDRO-1H-IMIDAZOLE HYDROBROMIDE
• Synonyms: 4,5-dihydro-2-(methylthio)-1H-imidazole monohydrobromide;2-(Methylthio)-4,5-dihydro-1h-imidazole hydrobromide, tech;2-METHYLSULFANYL-4,5-DIHYDRO-1H-IMIDAZOLE HYDROBROMIDE;2-(METHYLTHIO)-4,5-DIHYDRO-1H-IMIDAZOLE HYDROBROMIDE
• CAS NO: 40241-78-9
• Molecular Formula: BrH*C₄H₈N₂S
• Molecular Weight: 197.1
• EINECS: 254-854-6
• Mol File: 40241-78-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 157 °C
• Boiling Point: 186.8°Cat760mmHg
• Flash Point: 66.7°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.652mmHg at 25°C
• CAS DataBase Reference: 2-(METHYLTHIO)-4,5-DIHYDRO-1H-IMIDAZOLE HYDROBROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(METHYLTHIO)-4,5-DIHYDRO-1H-IMIDAZOLE HYDROBROMIDE(40241-78-9)
• EPA Substance Registry System: 2-(METHYLTHIO)-4,5-DIHYDRO-1H-IMIDAZOLE HYDROBROMIDE(40241-78-9)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 40241-78-9(Hazardous Substances Data)

Usage

Uses

2-(Methylthio)-2-imidazoline Hydrobromide can be prepared as phospholipase inhibitors.

InChI:InChI=1/C4H8N2S.BrH/c1-7-4-5-2-3-6-4;/h2-3H2,1H3,(H,5,6);1H

Upstream product

• 96-45-7 N,N'-ethylenethiourea 
• 74-83-9 methyl bromide 
• 20112-79-2 2-methylthioimidazoline 

Relevant articles and documents

Synthesis of five- and six-membered cyclic guanidines by guanylation with isothiouronium iodides and amines under mild conditions

Cyclic guanidine hydroiodides were obtained in one step by the reactions of isothiouronium iodides with an equimolar amount of various amines in tetrahydrofuran. The obtained hydroiodides were neutralized with sodium hydroxide or anionic exchange resin to afford the corresponding substituted cyclic guanidines in quantitative yields.

Process for making 2-amino-2-imidazoline, guanidine and 2-amino-3,4,5,6-tetrahydropyrimidine derivatives

The present invention provides a process for making 2-amino-2-imidazoline, guanidine, and 2-amino-3,4,5,6-tetrahydroyrimidine derivatives by preparing the corresponding activated 2-thio-subsituted-2-derivative in a two-step, one-pot procedure and by further reacting yields this isolated derivative with the appropriate amine or its salts in the presence of a proton source. The present process allows for the preparation of 2-amino-2-imidazolines, quanidines, and 2-amino-3,4,5,6-tetrahydropyrimidines under reaction conditions that eliminate the need for lengthy, costly, or multiple low yielding steps, and highly toxic reactants. This process allows for improved yields and product purity and provides additional synthetic flexibility.