20112-79-2

Basic information

• Product Name: 2-(METHYLTHIO)-2-IMIDAZOLINE
• Synonyms: AKOS BB-5618;2-(METHYLTHIO)-4,5-DIHYDRO-1H-IMIDAZOLE;2-(METHYLTHIO)-2-IMIDAZOLINE;2-METHYLSULFANYL-4,5-DIHYDRO-1H-IMIDAZOLE;4,5-dihydro-2-(methylthio)-1H-imidazole;2-(Methylthio)-1-imidazoline;Methyl 2-imidazoline-2-yl sulfide;Einecs 243-520-5
• CAS NO: 20112-79-2
• Molecular Formula: C₄H₈N₂S
• Molecular Weight: 116.18
• EINECS: 243-520-5
• Mol File: 20112-79-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 100-102 °C
• Boiling Point: 186.8±23.0 °C(Predicted)
• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.53±0.40(Predicted)
• CAS DataBase Reference: 2-(METHYLTHIO)-2-IMIDAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(METHYLTHIO)-2-IMIDAZOLINE(20112-79-2)
• EPA Substance Registry System: 2-(METHYLTHIO)-2-IMIDAZOLINE(20112-79-2)

Safety Data

• Hazardous Substances Data: 20112-79-2(Hazardous Substances Data)

Usage

General Description

2-(methylthio)-2-imidazoline is a chemical compound with the molecular formula C5H10N2S. It is a sulfur-containing heterocyclic compound and is derived from imidazoline. This chemical is commonly used as a corrosion inhibitor in oil and gas production, as well as in the transportation and storage of crude oil and petroleum products. It is also used as a stabilizer in the automotive and aviation industries to prevent the degradation of fuel and lubricants. Additionally, 2-(methylthio)-2-imidazoline has potential applications in pharmaceuticals and agrochemicals due to its unique structural properties and biological activities. Overall, this compound plays a crucial role in various industrial processes and has the potential for further development in different fields.

InChI:InChI=1/C4H8N2S/c1-7-4-5-2-3-6-4/h2-3H2,1H3,(H,5,6)

Upstream product

• 5464-11-9 2-methylthio-2-imidazoline hydroiodide 
• 96-45-7 N,N'-ethylenethiourea 
• 74-88-4 methyl iodide 
• 74-87-3 methylene chloride 
• 96-45-7 4,5-dihydro-1H-imidazole-2-thiol 
• 67-56-1 methanol 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 28118-54-9 2-methoxy-4,5-dihydro-1H-imidazole 
• 120-93-4 imidazolidone 
• 53914-10-6 10-(4-fluoro-benzyl)-2,10-dihydro-3H-imidazo[1,2-a]pyrido[2,3-d]pyrimidin-5-one 
• 83716-07-8 11-Benzyl-2,3-dihydro<1>benzothieno<3,2-d>imidazo<1,2-a>pyrimidin-5-(11H)-one 
• 30156-22-0 N-benzoyl-2-methylthio-2-imidazoline 
• 91912-29-7 methyl (2-imidazolidinylidene)cyanoacetate 
• 80-73-9 1,3-dimethyl-2-imidazolidinone 
• 7666-04-8 2-methylsulfanyl-1H-imidazole 
• 36318-56-6 (4,5-dihydro-1H-imidazol-2-yl)-o-tolyl-amine 
• 1848-75-5 2-(phenylimino)-imidazolidine 
• 4794-82-5 N-(imidazolidin-2-ylidene)-4-methylbenzenamine 
• 32725-30-7 2,3-dihydroimidazo<2,1-b>quinazolin-5(1H)-one 
• 40241-78-9 2-(methylthio)-4,5-dihydro-1H-imidazole hydrobromide 

Relevant articles and documents

Alkylation of ethylenethiourea with alcohols: A convenient synthesis of S-alkyl-isothioureas without toxic alkylating agents

The alkylation of ethylenethiourea with alcohols and aqueous acids (HCl, HBr, and HI) allows the synthesis of the respective S-alkyl-isothioureas in high yield and purity. Consistently high yields (91-98%) were obtained with 56% HI, the yields for 48% HBr (48-93%) and 37% HCl (36-85%) were lower and varied with the type of alcohol. The method is a convenient low-cost alternative to the use of alkyl iodides and an easy access to the S-tert-butyl isothiourea.

PROTEIN KINASE REGULATORS

The present invention provides, in part, novel compounds and pharmaceutically acceptable salts capable of modulating the activity of kinases, including Akt, ERK and MEK. Such modulation affects biological functions, for example, by inhibiting cell proliferation and/or inducing apoptosis. Also provided are pharmaceutical compositions and medicaments, comprising the compounds or salts of the invention, alone or in combination with other therapeutic agents or palliative agents.

Synthesis of five- and six-membered cyclic guanidines by guanylation with isothiouronium iodides and amines under mild conditions

Cyclic guanidine hydroiodides were obtained in one step by the reactions of isothiouronium iodides with an equimolar amount of various amines in tetrahydrofuran. The obtained hydroiodides were neutralized with sodium hydroxide or anionic exchange resin to afford the corresponding substituted cyclic guanidines in quantitative yields.

One-pot synthesis of iminoimidazolines under microwave irradiation in solvent-free conditions

Substituted iminoimidazolines were synthesized from a one-pot reaction of aromatic or hetero-aromatic amines with imidazolidine-2-thione under solvent-free conditions using microwave irradiation with good to excellent yields. Copyright Taylor & Francis Group, LLC.