40253-47-2 Usage
Uses
Used in Pharmaceutical Industry:
ETHYL 5-METHYL-2H-1,2,4-TRIAZOLE-3-CARBOXYLATE is used as a reagent for the synthesis of low-molecular derivatives of 1,2,4-triazole. These derivatives have potential applications in the development of pharmaceutical compounds due to their diverse chemical properties and reactivity.
Used in Cancer Treatment and Hypoxia Mediated Disease Industry:
ETHYL 5-METHYL-2H-1,2,4-TRIAZOLE-3-CARBOXYLATE is used as a reagent in the preparation of heterocyclic modulators of HIF (Hypoxia-Inducible Factor) activity. HIF is a transcription factor that plays a crucial role in the cellular response to low oxygen levels (hypoxia) and is often overexpressed in various cancers and other hypoxia-mediated diseases. By modulating HIF activity, these heterocyclic modulators can potentially be used in the treatment of cancer and other hypoxia-mediated diseases, offering a novel therapeutic approach to these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 40253-47-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,2,5 and 3 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 40253-47:
(7*4)+(6*0)+(5*2)+(4*5)+(3*3)+(2*4)+(1*7)=82
82 % 10 = 2
So 40253-47-2 is a valid CAS Registry Number.
40253-47-2Relevant academic research and scientific papers
Chudinov,Matveev,Zhurilo,Prutkov,Shvets
, p. 1273 - 1277 (2015)
An efficient general route to the synthesis of 5-substituted 1H-1,2,4-triazole-3-carboxylates was developed. N-acylamidrazones were obtained from carboxylic acid hydrazides and ethyl thiooxamate or ethyl 2-ethoxy-2-iminoacetate hydrochloride and then were
PREPARATION OF 3- AND 3,5-SUBSTITUTED 1,2,4-TRIAZOLES
Vanek, Tomas,Velkova, Vlasta,Gut, Jiri
, p. 2492 - 2495 (2007/10/02)
Ethyl 1,2,4-triazole-3-carboxylate (V), its 5-methyl and 5-phenyl derivatives (V and VI, respectively), 3-methyl-1,2,4-triazole (VIII), 3-phenyl-1,2,4-triazole (IX), 3,5-dimethyl-1,2,4-triazole (X), 3,5-diphenyl-1,2,4-triazole (XI) and 3-phenyl-5-methyl-1,2,4-triazole (XII) were prepared in 40-70percent yields by thermal cyclization of acylamidrazones III.
HETEROCYCLIC SYNTHESIS USING ETHYL CARBOETHOXYFORMIMIDATE
McKillop, Alexander,Henderson, Alan,Ray, Partha S.,Avendano, Carmen,Molinero, Encarnacion G.
, p. 3357 - 3360 (2007/10/02)
Ethyl carboethoxyformimidate is shown to be a versatile reagent for the synthesis of a variety of mono- and bicyclic heterocyclic systems.
