40261-59-4

Usage

Uses

Used in Pharmaceutical Industry:
3-FORMYL-1-PHENYL-1H-PYRAZOLE is used as a building block for the synthesis of biologically active compounds, contributing to the development of new pharmaceuticals. Its unique structure allows for the creation of diverse molecules with potential therapeutic applications.
Used in Organic Chemistry:
3-FORMYL-1-PHENYL-1H-PYRAZOLE is used as a reagent in organic chemistry reactions, facilitating the synthesis of complex organic molecules and aiding in various chemical processes.
Used in Research and Development:
3-FORMYL-1-PHENYL-1H-PYRAZOLE is used as a subject of study for its potential pharmacological properties, including its ability to act as a ligand for different receptors in the body, which could lead to the discovery of new therapeutic agents.
Used in Material Science:
3-FORMYL-1-PHENYL-1H-PYRAZOLE is used in the development of new materials and functional molecules, leveraging its unique chemical properties to create innovative substances with a range of applications.

Upstream product

• 7189-08-4 (1-phenyl-1H-pyrazol-3-yl)-methanol 
• 591-50-4 iodobenzene 
• 3920-50-1 3-formylpyrazole 
• 508191-77-3 3-phenylsydnone 
• 98700-40-4 3-(4-Fluorophenylimino)methyl-4,5-dihydro-5-morpholino-1-phenyl-1H-pyrazole 
• 98700-42-6 3-(4-Fluorophenylimino)methyl-1-phenyl-1H-pyrazole 
• 74073-15-7 4,5-Dihydro-4-methylene-5-morpholino-1-(4-nitrophenyl)-ν-triazole 
• 98700-38-0 4-[3-(4-Fluoro-phenyl)-5-methylene-4,5-dihydro-3H-[1,2,3]triazol-4-yl]-morpholine 
• 98700-39-1 4-methylene-4,5-dihydrotriazole 

Downstream Products

• 1226692-38-1 {6-methyl-8-[4-(1-phenyl-1H-pyrazol-3-ylmethyl)-[1,4]diazepan-1-yl]quinolin-7-yloxy}acetic acid ethyl ester 
• 1226694-03-6 1-(1-phenyl-1H-pyrazol-3-yl)propan-1-ol 
• 1195985-36-4 (1R)-1-phenyl-N-((1-phenyl-1H-pyrazol-3-yl)methyl)ethanamine 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class i and IIb histone deacetylase inhibitors

A novel series of HDAC inhibitors demonstrating class I and IIb subtype selectivity have been identified using a scaffold-hopping strategy. Several designed compounds showed better selectivity for class I and IIb over class IIa HDAC isoforms comparing to the FDA approved HDAC targeting drug SAHA. A representative lead compound 22 bearing a biphenyl moiety demonstrated promising class I and IIb HDAC isoforms selectivity and in vitro anticancer activities against several cancer cell lines. This work could serve as a fundamental platform for further exploration of selective HDAC inhibitors using designed molecular scaffold.

Discovery and optimization of substituted 1-(1-phenyl-1H-pyrazol-3-yl) methanamines as potent and efficacious type II calcimimetics

Our efforts to discover potent, orally bioavailable type II calcimimetic agents for the treatment of secondary hyperparathyroidism focused on the development of ring constrained analogues of the known calcimimetic R-568. The structure-activity relationships of various substituted heterocycles and their effects on the human calcium-sensing receptor are discussed. Pyrazole 15 was shown to be efficacious in a rat in vivo pharmacodynamic model.

NOVEL COMPOUNDS AS AGONIST FOR PPAR GAMMA AND PPAR ALPHA, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

The present invention relates to novel compounds accelerating the activity of Peroxisome proliferator-activated receptor gamma (PPARγ) and alpha (PPARα), processes of preparing the same, and pharmaceutical compositions containing the same as an active agent.

ν-Triazolines, XXIV-Pyrazolecarbaldehydes from 5-Amino-4,5-dihydro-4-methylene-ν-triazoles and Sydnones

The sydnones 1a-c react with the 4,5-dihydro-ν-triazoles 2a-c by long refluxing at 110-140 deg C affording via non-isolable adducts with elimination of CO2 and N2 and rearrangement a mixture of 4,5-dihydropyrazoles 3a-c, 3-pyrazolecarbaldehyde anils 4a-d, and 3-pyrazolecarbaldehydes 5a-c.Compounds 3 can be deaminated to give 4 which can be hydrolyzed to yield the 3-pyrazolecarbaldehydes 5. - The sydnones 6a,b react similarey with 2a to give a mixture of 4-pyrazolecarbaldehyde anils 7a,b and 4-pyrazolecarbaldehydes 8a,b.The structural assignments are based on spectroscopic and X-ray diffraction data.