471908-70-0Relevant academic research and scientific papers
Elaboration of 1-benzoyltetrahydroisoquinoline derivatives employing a Pictet-Spengler cyclization with α-chloro-α-phenylthioketones. Synthesis of O-methylvelucryptine
Silveira, Claudio C,Bernardi, Carmem R.,Braga, Antonio L.,Kaufman, Teodoro S.
, p. 8947 - 8950 (2007/10/03)
The reaction of N-tosyl-β-phenethylamines with α-chloro-α-phenylthioketones, leading to 1-benzoyl- and 1-pivaloyl-tetrahydroisoquinolines under modified Pictet-Spengler conditions, is described. The synthesis of O-methylvelucryptine employing this transformation as a key step is reported.
