402829-37-2

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 188923-20-8 trans-2,2-Dimethyl-6-hydroxy-5-amino-1,3-dioxepane 
• 98-88-4 benzoyl chloride 

Downstream Products

• 402829-40-7 (R)-1-((S)-2-Phenyl-4,5-dihydro-oxazol-4-yl)-hexadecan-1-ol 
• 402829-39-4 (S)-4-(S)-Oxiranyl-2-phenyl-4,5-dihydro-oxazole 
• 402829-38-3 Methanesulfonic acid (R)-2-hydroxy-1-((S)-2-phenyl-4,5-dihydro-oxazol-4-yl)-ethyl ester 

Relevant academic research and scientific papers

A highly efficient and versatile synthesis of D- and L-erythro-sphinganine

An expedient convergent synthesis of naturally occurring C18-erythro-sphinganine (dihydrosphingosine, 1) is presented. Chiral protected 2-amino-1,3,4-butanetriol 6 is readily transformed into oxazolinyl oxirane building block 9, which is alkylated by a copper mediated SN2 type nucleophilic substitution with tetradecylmagnesium chloride. This method promises to be suited for largescale syntheses and for rapid access to sphinganine analogues modified in the backbone.