402831-59-8

Upstream product

• 1125-88-8 benzaldehyde dimethyl acetal 
• 402831-56-5 ethyl 2-azido-2-deoxy-1-thio-α-D-mannopyranoside 
• 7473-36-1 (2R,3R,4S,5S,6R)-2-Ethylsulfanyl-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol 
• 219536-50-2 ethyl 4,6-O-benzylidene-1-thio-α-D-glucopyranoside 
• 604-69-3 β-D-glucose pentaacetate 
• 32934-24-0 ethyl 2,3,4,6-tetra-O-acetyl-1-thio-α-D-glycopyranoside 
• 402831-54-3 ethyl 2-azido-3,4,6-tri-O-acetyl-2-deoxy-1-thio-α-D-mannopyranoside 
• 139066-49-2 1,3,4,6-tetra-O-acetyl-2-azido-2-deoxy-α/β-D-mannopyranose 
• 97604-58-5 2-azido-2-deoxy-D-mannopyranose 
• 4710-95-6 D-mannosamine hydrochloride 

Relevant academic research and scientific papers

A versatile approach to the synthesis of mannosamine glycosides

O-Picoloyl protecting groups at remote positions can affect the stereoselectivity of glycosylation by means of the H-bond-mediated aglycone delivery (HAD) pathway. A new practical method for the stereoselective synthesis of β-glycosides of mannosamine is reported. The presence of the O-picoloyl group at the C-3 position of a mannosamine donor can provide high or complete stereocontrol. The method was also utilized for the synthesis of a biologically relevant trisaccharide related to the capsular polysaccharide of Streptococcus pneumoniae serotype 4. Also reported herein is a method to achieve complete α-manno stereoselectivity with mannosamine donors equipped with 3-O-benzoyl group. This journal is

A NOVEL SYNTHETIC NEISSERIA MENINGITIDIS SEROGROUP A OLIGOMER AND PROCESS FOR SYNTHESIZING THEREOF

The present invention relates to novel synthetic Neisseria meningitidis Serogroup A (hereinafter MenA) capsular polysaccharide repeating unit oligomer and a process for synthesizing said synthetic MenA capsular polysaccharide repeating unit oligomer. More specifically, the present invention relates to the chemical synthesis of the tetramer of MenA capsular polysaccharide repeating unit capable of being used as a candidate in the development of semisynthetic or fully synthetic conjugate vaccines as monovalent or as a part of combination vaccines against Meningococcal serogroup A bacterial infection.

A novel approach towards the stereoselective synthesis of 2-azido-2-deoxy-β-D-mannosides

Low temperature mannosylation of glycosyl acceptors under the agency of S-(4-methoxyphenyl) benzenethiosulfinate (MPBT) and trifluoromethanesulfonic anhydride (Tf2O) with p-methoxyphenyl 2-azido-3-O-benzyl-4,6-O-benzylidene-2-deoxy-1-thio-α-D-