402831-61-2Relevant academic research and scientific papers
Synthesis of staphylococcus aureus type 5 trisaccharide repeating unit: Solving the problem of lactamization
Gagarinov, Ivan A.,Fang, Tao,Liu, Lin,Srivastava, Apoorva D.,Boons, Geert-Jan
, p. 928 - 931 (2015/04/13)
The chemical synthesis of an orthogonally protected trisaccharide derived from the polysaccharide of Staphylococcus aureus Type 5, which is an attractive candidate for the development of immunotherapies, is described. The challenging α-fucosylation and β-mannosylation are addressed through the careful choice of protecting groups. Lactamization of a β-d-ManpNAcA moiety during deprotection was avoided by a late stage oxidation approach. Versatility of the trisaccharide was demonstrated by its transformation into a spacer-containing repeating unit suitable for immunological investigations.
A novel approach towards the stereoselective synthesis of 2-azido-2-deoxy-β-D-mannosides
Litjens, Remy E.J.N,Leeuwenburgh, Michiel A,Van Der Marel, Gijsbert A,Van Boom, Jacques H
, p. 8693 - 8696 (2007/10/03)
Low temperature mannosylation of glycosyl acceptors under the agency of S-(4-methoxyphenyl) benzenethiosulfinate (MPBT) and trifluoromethanesulfonic anhydride (Tf2O) with p-methoxyphenyl 2-azido-3-O-benzyl-4,6-O-benzylidene-2-deoxy-1-thio-α-D-
