402859-58-9

Upstream product

• 609-67-6 2-Iodobenzoyl chloride 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 88-67-5 2-Iodobenzoic acid 
• 17596-79-1 (2S)-2-phenyl-1-propanamine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Relevant academic research and scientific papers

Mapping the structural boundaries of quasiracemate fractional crystallization using 2-substituted diarylamides

Video-assisted hot stage polarized light microscopy of 55 quasienantiomeric pairs, constructed from 22 chiral diarylamides that systematically differ in topology, reveals the structural boundaries of molecular shape to supramolecular assembly.

Palladium(II)-catalyzed cyclizative cross-coupling of ortho-alkynylanilines with ortho-alkynylbenzamides under aerobic conditions

Born to couple: The Pd(OAc)2-catalyzed reaction of o-alkynylanilines (1) with o-alkynylbenzamides (2) affords the cyclizative cross-coupling products 3 in good to excellent yields. Three bonds are created in the formation of two heterocycles tethered by a tetrasubstituted double bond. Mechanistic studies indicate that the reaction is initiated by aminopalladation with subsequent oxypalladation, N-demethylation, and reductive elimination. Copyright

Water soluble phosphines Part XV. Syntheses of multiply functionalized and chiral phospine ligands by Pd-catalyzed P-C and C-C coupling reactions

Phosphine ligands containing mono- and multiply substituted aromatic substituents (1-13, 19a and 19b) are accessible in high yields by palladium-catalyzed P-C coupling reactions between primary, secondary or disecondary phosphines and iodo- or bromoaromatic compounds. The reaction is of broad applicability and compatible with electron donor or electron acceptor substituents in ortho, meta or para position to the halogen in the aromatic ring systems. It may be performed in protic and aprotic solvents. The chiral spirocyclic boronato complex 15a is formed upon reaction of 3 with boric acid, while with benzeneboronic acid 15c with a peripheral Lewis acid group is obtained. The Pd-mediated P-C coupling reaction of primary phosphines proceeds stepwise, tailor-made chiral secondary (16) and tertiary phosphines (17) being formed in high yield. Through combination with Suzuki-type C-C coupling reactions, the scope of Pd-catalyzed P-C coupling may be extended further, novel ligands (20a, 20b, 21a, 21b) with biphenylyl substituents being accessible. The X-ray structures of the salicylic acid derivative 3 (space group P1) and of ortho-iso-propylphenyl-diphenylphosphine 6 (space group Pbca) have been determined.

Highly effective, easily accessible screw-sense-determining end group in the asymmetric polymerization of 1,2-diisocyanobenzenes

Enantiopure helical poly(quinoxaline-2,3-diyl) was formed stereoselectively in the polymerization of 1,2-diisocyanobenzene using a new organopalladium initiator bearing the (4S,5S)-N-acyl-4,5-dihydro-4,5-diphenyl-1H-imidazol-2-yl group as the polymer-end screw-sense-determinant.