40290-36-6

Usage

Uses

1,2-DIPALMITOYL-3-IODO-RAC-3-DEOXYGLYCEROL is used as a component in the preparation of glycolipid amphipathic micellar delivery systems for DNA and RNA biological active polyions. The expression is: 1,2-DIPALMITOYL-3-IODO-RAC-3-DEOXYGLYCEROL is used as a component for the formation of micellar delivery systems for [application reason].
Used in Pharmaceutical Industry:
1,2-DIPALMITOYL-3-IODO-RAC-3-DEOXYGLYCEROL is used as a component in the development of drug delivery systems, specifically for the encapsulation and delivery of DNA and RNA molecules. This application is particularly relevant in the field of gene therapy, where the efficient delivery of genetic material is crucial for the treatment of various diseases and conditions.
The use of 1,2-DIPALMITOYL-3-IODO-RAC-3-DEOXYGLYCEROL in the creation of micellar delivery systems allows for the protection of sensitive DNA and RNA molecules from degradation, while also facilitating their transport across biological barriers. This enhances the bioavailability and therapeutic efficacy of these genetic materials, making them more effective in their intended applications.

Upstream product

• 30334-71-5 1,2-dipalmitoyl-sn-glycerol 
• 554-10-9 3-iodo-propane-1,2-diol 
• 112-67-4 n-hexadecanoyl chloride 

Relevant academic research and scientific papers

A METHOD FOR MODIFICATION OF PEPTIDES IMMOBILIZED ON A SOLID SUPPORT BY TRACELESS REDUCTIVELY CLEAVABLE LINKER MOLECULES

The present invention relates to a method for modifying and purifying peptides comprising an immobilizing step, a modification step and a releasing step. In the immobilizing step, a crude linker-tagged peptide L-P is coupled to a solid support yielding an immobilized linker-tagged peptide S-L-P. Subsequently, the immobilized linker-tagged peptide S-L-P is modified with one or more organic molecules yielding an immobilized linker-tagged peptide S-L-mP. Finally, the modified peptide is released via a reduced intermediate RI. The linker molecule is a compound of formula 1, X-Tbb-Vaa-U-Y-Z (1), which can be coupled to a purification resin via the moiety X and to a peptide via the moiety Y under the release of the leaving group Z. T is an optional spacer moiety and V is an optional electron withdrawing moiety. U is an aryl or 5- or 6-membered heteroaryl moiety bound to at least one electron withdrawing moiety V, W or E. The linker is stable under acidic conditions and releases the peptide upon addition of a reducing agent.

Liposome, preparation method, of liposome, liposome assembly and carrying liposome complex (by machine translation)

The liposome according, to the present invention has the properties such, as that of the. liposome according to the present invention in the form (I), of ,L a liposome according to the present invention in the form of, a liposome according to the L present invention, in the form of a. liposome according to the present (I) invention in the form, of a, liposome according to, and the present invention in the, form of a liposome according to the present, invention. (by machine translation)