402939-95-1Relevant articles and documents
Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents
Saccoliti, Francesco,Madia, Valentina Noemi,Tudino, Valeria,De Leo, Alessandro,Pescatori, Luca,Messore, Antonella,De Vita, Daniela,Scipione, Luigi,Brun, Reto,Kaiser, Marcel,M?ser, Pascal,Calvet, Claudia M.,Jennings, Gareth K.,Podust, Larissa M.,Pepe, Giacomo,Cirilli, Roberto,Faggi, Cristina,Di Marco, Annalise,Battista, Maria Rosaria,Summa, Vincenzo,Costi, Roberta,Di Santo, Roberto
supporting information, p. 1330 - 1347 (2019/02/24)
We have designed and synthesized a series of new imidazole-based compounds structurally related to an antiprotozoal agent with nanomolar activity which we identified recently. The new analogues possess micromolar activities against Trypanosoma brucei rhod
Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents
Dinesha,Viveka, Shivapura,Priya, Bolli Keerthi,Pai, K. Sreedhara Ranganath,Naveen, Shivalingegowda,Lokanath, Neratur K.,Nagaraja, Gundibasappa Karikannar
, p. 25 - 32 (2015/10/12)
Breast cancer is probably the most prevalent cancer in women. The development of resistance to therapeutic agents and lack of targeted therapy for breast cancer cells provide motivation to identify new compounds for the treatment. With this objective in m
Design, synthesis, and bioactivities screening of a diaryl ketone-inspired pesticide molecular library as derived from natural products
Zhang, Hong,Jin, Hong,Ji, Lan-Zhu,Tao, Ke,Liu, Wei,Zhao, Hao-Yu,Hou, Tai-Ping
experimental part, p. 94 - 100 (2012/06/01)
Three natural products, 1,5-diphenylpentan-1-one, 1,5-diphenylpent-2-en-1-one, and 3-hydroxy-1,5-diphenylpentan-1-one, with good insecticidal activities were extracted from Stellera chamaejasme L. Based on their shared diaryl ketone moiety as 'pharmacophores', a series of diaryl ketones were synthesized and tested for insecticidal activity, acetylcholinesterase inhibitory activity, and antifungal activity. All synthesized compounds showed poor insecticidal and acetylcholinesterase inhibitory activities. Compound III with a furyl ring showed strong activities against plant pathogenic fungi. The IC50 of compound (E)-1-(2,4-dichlorophenyl)-3-(furan-2-yl)- -prop-2-en-1-one (III2) was 1.20mg/L against Rhizoctonia solani, suggesting its strong potential as a novel antifungal drug.
