1166397-39-2

Basic information

• Product Name: HexanaMide, 3-aMino-N-cyclopropyl-2-hydroxy-, Monohydrochloride
• Synonyms: HexanaMide, 3-aMino-N-cyclopropyl-2-hydroxy-, Monohydrochloride;3-Amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride
• CAS NO: 1166397-39-2
• Molecular Formula: C9H19ClN2O2
• Molecular Weight: 222.71236
• Mol File: 1166397-39-2.mol
• Article Data: 29

Chemical Properties

• Appearance: /
• CAS DataBase Reference: HexanaMide, 3-aMino-N-cyclopropyl-2-hydroxy-, Monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: HexanaMide, 3-aMino-N-cyclopropyl-2-hydroxy-, Monohydrochloride(1166397-39-2)
• EPA Substance Registry System: HexanaMide, 3-aMino-N-cyclopropyl-2-hydroxy-, Monohydrochloride(1166397-39-2)

Safety Data

• Hazardous Substances Data: 1166397-39-2(Hazardous Substances Data)

Upstream product

• 928-95-0 (E)-2-Hexen-1-ol 
• 959709-86-5 methyl (2S,3S) 3-amino-2-hydroxyhexanoate hydrochloride salt 
• 765-30-0 Cyclopropylamine 
• 608520-05-4 (3R,2S)-3-propyloxirane-2-carboxylic acid 
• 92418-71-8 (2R,3R)-2,3-epoxy-1-hexanol 
• 166196-06-1 3-tert-butoxycarbonylamino-2-hydroxyhexanoic acid 
• 367258-42-2 2-hydroxy-3-nitrohexanoic acid 
• 166196-05-0 3-amino-2-hydroxyhexanoic acid 
• 111003-36-2 ((2R,3S)-3-propyloxiran-2-yl)methanol 
• 959709-83-2 (4S,5S)-N-cyclopropyl-2-methyl-4-propyl-4,5-dihydro-1,3-oxazole-5-carboxamide 
• 959709-91-2 (4S,5S)-N-cyclopropyl-2-isopropyl-4-propyl-4,5-dihydro-1,3-oxazole-5-carboxamide 
• 944716-71-6 (2S,3S)-N-cyclopropyl-3-(tert-butoxycarbonyl)amino-2-hydroxyhexanoic acid amide 
• 950842-31-6 (2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide deoxycholic acid salt 
• 160801-73-0 (S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopentan-2-ylcarbamate 

Downstream Products

• 402959-36-8 C₃₆H₅₅N₇O₆ 
• 402957-28-2 (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide 

Relevant articles and documents

Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors

Herein, we report the synthesis and structure-activity relationship studies of new analogs of boceprevir 1 and telaprevir 2. Introduction of azetidine and spiroazetidines as a P2 substituent that replaced the pyrrolidine moiety of 1 and 2 led to the disco

A pulls Swiss Wei intermediates for the synthesis of the new method

The invention discloses a method for preparing (3S)-3-amino-2-hydroxyl-N-cyclopropylhexanamide. The compound can be used as an important intermediate for preparing telaprevir. According to the invention, ethyl butyrylacetate is used as a starting raw material, and through steps of helogenation, substitution, amination, reduction, hydrolysis, deprotection, resolution and the like, (3S)-3-amino-2-hydroxyl-N-cyclopropylhexanamide is prepared. The method provided by the invention has advantages as follows: raw materials are cheap and easily available; reaction yield is high; and costs are high.

SYNTHESIS OF AN INTERMEDIATE OF AN ANTIVIRAL COMPOUND

Process for the preparation of a cyclopropylamide compound which is useful as a structural unit in a process for the preparation of a viral protease inhibitor.