403-61-2

Basic information

• Product Name: 4-(2-CHLORO-1,1,2-TRIFLUORO-ETHOXY)-PHENYLAMINE
• Synonyms: 4-(2-CHLORO-1,1,2-TRIFLUOROETHOXY)-ANILINE;4-(2-CHLORO-1,1,2-TRIFLUORO-ETHOXY)-PHENYLAMINE
• CAS NO: 403-61-2
• Molecular Formula: C₈H₇ClF₃NO
• Molecular Weight: 225.6
• Mol File: 403-61-2.mol

Chemical Properties

• Boiling Point: 263.2 °C at 760 mmHg
• Flash Point: 113 °C
• Appearance: /
• Density: 1.406 g/cm³
• Vapor Pressure: 0.0104mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: 4-(2-CHLORO-1,1,2-TRIFLUORO-ETHOXY)-PHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-CHLORO-1,1,2-TRIFLUORO-ETHOXY)-PHENYLAMINE(403-61-2)
• EPA Substance Registry System: 4-(2-CHLORO-1,1,2-TRIFLUORO-ETHOXY)-PHENYLAMINE(403-61-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 403-61-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-CHLORO-1,1,2-TRIFLUORO-ETHOXY)-PHENYLAMINE is used as a synthetic intermediate for the creation of various pharmaceuticals, leveraging its unique functional groups to impart specific therapeutic properties to the final drug molecules.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(2-CHLORO-1,1,2-TRIFLUORO-ETHOXY)-PHENYLAMINE serves as a key building block in the synthesis of compounds designed to protect crops and enhance agricultural productivity, capitalizing on its reactive groups to tailor-made molecules with targeted pesticidal or herbicidal activities.
Used in Organic Synthesis:
4-(2-CHLORO-1,1,2-TRIFLUORO-ETHOXY)-PHENYLAMINE is utilized as a versatile reagent in organic synthesis, where its chloro and trifluoroethoxy groups participate in various chemical reactions to form complex organic molecules for a broad spectrum of applications, from materials science to specialty chemicals.

InChI:InChI=1/C8H7ClF3NO/c9-7(10)8(11,12)14-6-3-1-5(13)2-4-6/h1-4,7H,13H2

Upstream product

• 3832-98-2 4-(1,1,2-trifluoro-2-chloroethoxy)acetanilide 
• 103-90-2 4-acetaminophenol 
• 100-02-7 4-nitro-phenol 
• 405-44-7 (2-chloro-1,1,2-trifluoro-ethyl)-(4-nitro-phenyl)-ether 

Downstream Products

• 3832-98-2 4-(1,1,2-trifluoro-2-chloroethoxy)acetanilide 
• 2823-24-7 benzoic acid-[4-(2-chloro-1,1,2-trifluoro-ethoxy)-anilide] 
• 88553-89-3 4-(1,1,2-trifluoro-2-chloroethoxy)phenol 
• 28002-00-8 C₁₁H₁₂ClF₃N₂O₃ 
• 27954-28-5 N-[4-(1',1',2'-trifluoro-2'-chloro-ethoxy)-phenyl]-N',N'-dimethylurea 
• 27869-28-9 N-[4-(1',1',2'-trifluoro-2'-chloroethoxy)-phenyl]-N'-methylurea 
• 55225-44-0 4,4'-bis(2-chloro-1,1,2-trifluoroethoxy)carbanilide 
• 55225-84-8 4,4-sulfonylbis(4'-(2-chloro-1,1,2-trifluoroethoxy)carbanilide) 
• 27869-29-0 N-[4-(1',1',2'-trifluoro-2'-chloro-ethoxy)phenyl]-N'-methoxyurea 

Relevant articles and documents

Phenols reactions with 1,1-difluorodichloroethene, 1,2-di(fluorochloro) ethene, and trifluorochloroethene

Phenols containing in the para-position of the benzene ring substituents of various electronic character add to 1,1-difluorodichloroethene in acetone in the presence of potassium hydroxide. A similar reaction with 1,2-di(fluorochloro)ethene occurs only in

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