403-96-3

Basic information

• Product Name: 1,3-bis[3-(trifluoromethyl)phenyl]urea
• CAS NO: 403-96-3
• Molecular Formula: C₁₅H₁₀F₆N₂O
• Molecular Weight: 348.2431
• Mol File: 403-96-3.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 280.3°C at 760 mmHg
• Flash Point: 123.3°C
• Density: 1.47g/cm³
• Vapor Pressure: 0.00383mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: 1,3-bis[3-(trifluoromethyl)phenyl]urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis[3-(trifluoromethyl)phenyl]urea(403-96-3)
• EPA Substance Registry System: 1,3-bis[3-(trifluoromethyl)phenyl]urea(403-96-3)

Safety Data

• Hazardous Substances Data: 403-96-3(Hazardous Substances Data)

Usage

General Description

1,3-bis[3-(trifluoromethyl)phenyl]urea, also known as flupoxam, is a white crystalline compound that belongs to the urea class of chemicals. It is commonly used as a pesticide and herbicide due to its ability to prevent the growth of unwanted plants and pests. This chemical has a molecular formula of C15H10F6N2O and a molecular weight of 358.24 g/mol. It is also known for its high water solubility and stability under various environmental conditions. Additionally, 1,3-bis[3-(trifluoromethyl)phenyl]urea has low mammalian toxicity, making it a relatively safe option for agricultural use. However, it is important to handle this chemical with care as it can be harmful if ingested or inhaled.

Upstream product

• 75-13-8 isocyanic acid 
• 98-16-8 3-trifluoromethylaniline 
• 57-13-6 urea 
• 530-62-1 1,1'-carbonyldiimidazole 
• 124-38-9 carbon dioxide 
• 69563-05-9 (3-Trifluoromethyl-phenyl)-trimethylsilanyl-amine 
• 312944-36-8 (1H-benzo[d][1,2,3]triazol-1-yl)(3-(trifluoromethyl)phenyl)methanone 
• 95-14-7 1,2,3-Benzotriazole 
• 454-92-2 3-(trifluoromethyl)benzoic acid 
• 201230-82-2 carbon monoxide 
• 98-46-4 3-trifluoromethylnitrobenzene 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 4342-07-8 5-amino-1,2,3-triazole-4-carboxamide 
• 329-01-1 1-isocyanato-3-trifluoromethyl-benzene 

Downstream Products

• 98-16-8 3-trifluoromethylaniline 
• 103-71-9 phenyl isocyanate 

Relevant articles and documents

Urea-Catalyzed Vinyl Carbocation Formation Enables Mild Functionalization of Unactivated C-H Bonds

Herein we report the 3,5-bistrifluoromethylphenyl urea-catalyzed functionalization of unactivated C-H bonds. In this system, the urea catalyst mediates the formation of high-energy vinyl carbocations that undergo facile C-H insertion and Friedel-Crafts re

Stoichiometric Reactions of CO2 and Indium-Silylamides and Catalytic Synthesis of Ureas

The indium compounds In(N(SiMe3)2)2Cl?THF (2) and In(N(SiMe3)2)Cl2?(THF)n (3) were shown to react with CO2 to give [(Me3Si)2N)InX(μ-OSiMe3)]2 (X=N(SiMe3)2 4, Cl 5). 0.05–2.0 mol % of the species 3 acts as a pre-catalyst for the conversion of aryl and alkyl silylamines under CO2 (2–3 atm) to give the corresponding ureas in 70–99 % yields. A proposed mechanism is supported by experimental and computational data.

Palladium-catalyzed synthesis of symmetrical urea derivatives by oxidative carbonylation of primary amines in carbon dioxide medium

An efficient palladium-catalyzed synthesis of symmetrically disubstituted ureas via oxidative carbonylation of primary amines is described. The reactions are carried out in the presence of a large excess of carbon dioxide as reaction medium or under solvent-free conditions. The adopted catalyst such as potassium tetraiodopalladate, stable and easy to prepare, allows the use of air as a cheap oxidizing agent. The reactions yield urea and water as the only by-product and proceed with high efficiency with aliphatic and aromatic amines as well. While with primary aliphatic amines, no significant improvement on reactivity is observed when carbon dioxide is used as a solvent, in comparison with the conventional ones, a remarkable high efficiency is obtained with aromatic amines, which shows a dramatic increase in the performance of the catalyst, in terms of turnover number (TON), the highest known so far for this kind of process. Reactions take place in two-phase systems consisting of a homogeneous liquid phase formed by the CO2 expanded amine solution containing the catalyst and a supercritical phase of CO2, CO, O2, and N2.