40313-65-3

Usage

Uses

Used in Organic Synthesis:
[5-(3-CHLORO-PHENYL)-FURAN-2-YL]-METHANOL is used as an intermediate in the synthesis of various organic compounds due to its reactive functional groups and unique structural features.
Used in Medicinal Chemistry:
[5-(3-CHLORO-PHENYL)-FURAN-2-YL]-METHANOL is used as a building block in the development of new pharmaceuticals, as its structure may contribute to biological activities and potential therapeutic applications.
Used in Drug Development:
[5-(3-CHLORO-PHENYL)-FURAN-2-YL]-METHANOL is used as a potential candidate for drug development in the pharmaceutical industry, given its unique structural features that may lead to the discovery of new therapeutic agents.
Further research and studies are required to fully understand the potential uses and properties of [5-(3-CHLORO-PHENYL)-FURAN-2-YL]-METHANOL, as its biological activities and applications in pharmaceutical research are still being explored.

Upstream product

• 92973-26-7 5-(3-chlorophenyl)furan-2-carbonyl chloride 
• 88-14-2 2-furanoic acid 
• 41019-44-7 5-(3-chlorophenyl) furan-2-carboxylic acid 
• 63503-60-6 3-chlorophenylboronic acid 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 108-42-9 3-chloro-aniline 
• 22078-59-7 5-(3-chlorophenyl)-2-furancarboxaldehyde 
• 98-01-1 furfural 

Downstream Products

• 1032338-23-0 C₁₉H₁₂Cl₃NO₄ 
• 1032337-99-7 C₁₉H₁₂ClF₂NO₄ 
• 1338233-17-2 1-((5-(3-chlorophenyl)furan-2-yl)methyl)pyrimidine-2,4(1H,3H)dione 
• 40941-28-4 C₁₁H₈BrClO 

Relevant academic research and scientific papers

Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors

In this present study, a series of 5-phenyl-2-furan and 4-phenyl-2-oxazole derivatives were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. In vitro results showed that the synthesized compounds exhibited considerable inhibitory ac

PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS

Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.

Synthesis and evaluation of compounds that induce readthrough of premature termination codons

A structure-activity relationship (SAR) study was carried out to identify novel, small molecular weight compounds which induce readthrough of premature termination codons. In particular, analogs of RTC13, 1, were evaluated. In addition, hypothesizing that these compounds exhibit their activity by binding to the ribosome, we prepared the hybrid analogs 13 containing pyrimidine bases and these also showed good readthrough activity.

Synthesis and fungicidal activity of aryl carbamic acid-5-aryl-2- furanmethyl ester

Chitin, a major structural component of insect cuticle and fungus cell wall but absent in plants and vertebrates, is regarded as a safe and selective target for pest control agents. Chitin synthesis inhibitors (CSIs) have been well-known as insect growth regulators (IGRs) but rarely found as fungicides in agriculture. To find novel CSIs with good activity, benzoylphenylurea, a typical kind of CSIs, was chosen as the lead compound and 26 novel aryl carbamic acid-5-aryl-2-furanmethyl esters were designed by converting the urea linkages of benzoylphenylureas to carbamic acid esters and changing the aniline parts into furanmethyl groups. The title compounds were synthesized and their structures confirmed by IR, 1H NMR, and elemental analysis. Preliminary insecticidal and fungicidal bioassays were carried out. The results indicated that the title compounds had no insecticidal effect on Culex pipiens pallens and Plutella xylostella Linnaeus, but most compounds exhibited good fungicidal activities against Corynespora cassiicola, Thanatephorus cucumeris, Botrytis cinerea, and Fusarium oxysporum. In particular, compounds V-4, V-6, V-7, and V-8 showed better activities against the four strains than those of the commercialized fungicides. The morphologic result suggested that compound V-21 had disturbed the cell wall formation of C. cassiicola. The results indicated that modification on the urea linkage of benzoylphenylurea was an effective way to discover new candidates for fungicides.