40319-63-9Relevant academic research and scientific papers
Use of fluoroform as a source of difluorocarbene in the synthesis of N-CF2H heterocycles and difluoromethoxypyridines
Thomoson, Charles S.,Wang, Linhua,Dolbier, William R.
, p. 34 - 39 (2015/03/04)
Fluoroform is used as a source of difluorocarbene to convert various N-, O-, and C-nucleophiles to their difluoromethylated derivatives. Imidazole, benzimidazole, benztriazole, hydroxypyridines, and their derivatives underwent reaction at moderate temperatures and atmospheric pressure, using potassium hydroxide as base in a two-phase (water/acetonitrile) process to provide moderate to good yields of the respective products. Nitrophenols required addition of a co-solvent (methanol) to obtain good yields of products.
Synthesis and antibacterial activity of 6-difluoromethoxy-7-piperazinyl-3-quinolinecarboxylic acid derivatives
Krishnan,Lang Jr.
, p. 458 - 460 (2007/10/02)
A series of novel 3-quinolinecarboxylic acid derivatives has been prepared and their antibacterial activity evaluated. These derivatives were characterized by a difluoromethoxy group attached to the 6-position and substituted piperazinyl groups attached to the 7-position.
