40319-63-9

Basic information

• Product Name: 2-Chloro-1-(difluoromethoxy)-4-nitro-benzene
• Synonyms: 2-Chloro-1-(difluoromethoxy)-4-nitro-benzene
• CAS NO: 40319-63-9
• Molecular Formula: C₇H₄ClF₂NO₃
• Molecular Weight: 223.5613664
• Mol File: 40319-63-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Chloro-1-(difluoromethoxy)-4-nitro-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-1-(difluoromethoxy)-4-nitro-benzene(40319-63-9)
• EPA Substance Registry System: 2-Chloro-1-(difluoromethoxy)-4-nitro-benzene(40319-63-9)

Safety Data

• Hazardous Substances Data: 40319-63-9(Hazardous Substances Data)

Usage

Uses

2-Chloro-1-(difluoromethoxy)-4-nitrobenzene

Upstream product

• 75-46-7 trifluoromethan 
• 619-08-9 2-chloro-4-nitrophenol 
• 75-45-6 Chlorodifluoromethane 

Downstream Products

• 115700-24-8 3-Chloro-4-difluoromethoxy-phenylamine; hydrochloride 
• 115712-80-6 <<3-chloro-4-(difluoromethoxy)phenyl>amino>methylenepropanedioic acid diethyl ester 

Relevant articles and documents

Use of fluoroform as a source of difluorocarbene in the synthesis of N-CF2H heterocycles and difluoromethoxypyridines

Fluoroform is used as a source of difluorocarbene to convert various N-, O-, and C-nucleophiles to their difluoromethylated derivatives. Imidazole, benzimidazole, benztriazole, hydroxypyridines, and their derivatives underwent reaction at moderate temperatures and atmospheric pressure, using potassium hydroxide as base in a two-phase (water/acetonitrile) process to provide moderate to good yields of the respective products. Nitrophenols required addition of a co-solvent (methanol) to obtain good yields of products.