40326-25-8

Basic information

• Product Name: Benzeneacetonitrile, a-phenyl-a-[(trimethylsilyl)oxy]-
• CAS NO: 40326-25-8
• Molecular Formula: C17H19NOSi
• Molecular Weight: 281.429
• Mol File: 40326-25-8.mol
• Article Data: 49

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, a-phenyl-a-[(trimethylsilyl)oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, a-phenyl-a-[(trimethylsilyl)oxy]-(40326-25-8)
• EPA Substance Registry System: Benzeneacetonitrile, a-phenyl-a-[(trimethylsilyl)oxy]-(40326-25-8)

Safety Data

• Hazardous Substances Data: 40326-25-8(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 119-61-9 benzophenone 
• 151-50-8 potassium cyanide 
• 91-01-0 1,1-Diphenylmethanol 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 370557-71-4 α-(4-Fluorobenzoyl)diphenylmethanol 
• 4746-87-6 benzilamide 
• 4746-48-9 2-hydroxy-2,2-diphenylacetonitrile 
• 4746-86-5 hydroxy-diphenyl-acetaldehyde 
• 86-29-3 Diphenylacetonitrile 
• 1013-88-3 Benzophenone imine 
• 93554-78-0 amino-diphenyl-acetonitrile; hydrochloride 

Relevant articles and documents

Application of an Electrochemical Microflow Reactor for Cyanosilylation: Machine Learning-Assisted Exploration of Suitable Reaction Conditions for Semi-Large-Scale Synthesis

Cyanosilylation of carbonyl compounds provides protected cyanohydrins, which can be converted into many kinds of compounds such as amino alcohols, amides, esters, and carboxylic acids. In particular, the use of trimethylsilyl cyanide as the sole carbon source can avoid the need for more toxic inorganic cyanides. In this paper, we describe an electrochemically initiated cyanosilylation of carbonyl compounds and its application to a microflow reactor. Furthermore, to identify suitable reaction conditions, which reflect considerations beyond simply a high yield, we demonstrate machine learning-assisted optimization. Machine learning can be used to adjust the current and flow rate at the same time and identify the conditions needed to achieve the best productivity.

n-Butyllithium as a highly efficient precatalyst for cyanosilylation of aldehydes and ketones

A highly efficient cyanosilylation protocol mediated by the easily availablen-BuLi with a wide range of aldehydes and ketones was developed. This protocol features excellent yields with very lown-BuLi loadings (0.01-0.05 mol%) at room temperature, solvent

Synthesis of cyanooxovanadate and cyanosilylation of ketones

The cyanosilylation was performed by using metavanadate catalysts, and in situ measurements revealed the formation of [VO2(CN)3]2- and [VO4TMS2]- under reaction conditions. The reaction of [VO2(CN)3]2-, trimethylsilyl cyanide (TMSCN), and water afforded [