40334-34-7Relevant academic research and scientific papers
Phosphonamidates are the first phosphorus-based zinc binding motif to show inhibition of β-class carbonic anhydrases from bacteria, fungi, and protozoa
Alissa, Siham A.,Alghulikah, Hanan A.,Alothman, Zeid A.,Osman, Sameh M.,Del Prete, Sonia,Capasso, Clemente,Nocentini, Alessio,Supuran, Claudiu T.
, p. 59 - 64 (2019/11/11)
A primary strategy to combat antimicrobial resistance is the identification of novel therapeutic targets and anti-infectives with alternative mechanisms of action. The inhibition of the metalloenzymes carbonic anhydrases (CAs, EC 4.2.1.1) from pathogens (
Phosphorus versus Sulfur: Discovery of Benzenephosphonamidates as Versatile Sulfonamide-Mimic Chemotypes Acting as Carbonic Anhydrase Inhibitors
Nocentini, Alessio,Gratteri, Paola,Supuran, Claudiu T.
supporting information, p. 1188 - 1192 (2019/01/04)
The first zinc-binding group (ZBG) to have been identified as inhibitor of the metallo-enzymes carbonic anhydrases (CA, EC 4.2.1.1) was the sulfonamide. From then on several classes of zinc-binders have been described. This work reports the benzenephospon
