3648-58-6

Usage

Uses

Used in Organic Synthesis:
4-(4-METHOXY-PHENYL)-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID is used as a building block for the synthesis of complex organic molecules, leveraging its unique structure and functional groups to facilitate the creation of a wide range of compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-(4-METHOXY-PHENYL)-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID is used as an intermediate for the preparation of pharmaceuticals, contributing to the development of new drugs with potential therapeutic benefits.
Used in Pharmaceutical Industry:
4-(4-METHOXY-PHENYL)-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID is utilized in the pharmaceutical industry as a key component in the formulation of various drugs, taking advantage of its chemical properties to enhance drug efficacy and target specific biological pathways.
Used in Research and Development:
4-(4-METHOXY-PHENYL)-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID is employed in research and development settings to explore its potential biological activities, with the aim of discovering new therapeutic applications and improving existing pharmaceutical formulations.

Upstream product

• 3648-78-0 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonitrile 
• 104-47-2 p-methoxybenzylnitrile 
• 5414-19-7 1,1'-oxybis(2-bromo-ethane) 

Downstream Products

• 4035-86-3 4-(4-methoxyphenyl)tetrahydro-2-pyran-4-carbonyl chloride 
• 885561-38-6 ethyl 4-[(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonylamino]benzoate 
• 573949-85-6 4-(4-methoxyphenyl)-N-[4-(morpholin-4-ylcarbonyl)-phenyl]tetrahydro-2H-pyran-4-carboxamide 
• 664993-51-5 4-(4-methoxyphenyl)-N-[4-(2-methoxy-5-methylphenylcarbamoyl)phenyl]tetrahydro-2H-pyran-4-carboxamide 
• 1035261-19-8 diethyl 2-(4-(4-methoxyphenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate 

Relevant academic research and scientific papers

PROSTAGLANDIN E2 (PGE2) EP4 RECEPTOR ANTAGONISTS

The present invention relates to novel compounds of formula (I) and pharmaceutical compositions containing these compounds. The compounds provided herein can act as prostaglandin E2 (PGE2) EP4 receptor antagonists, which renders them highly advantageous for use in therapy, particularly in the treatment or prevention of cancer, a neovascular eye disease, inflammatory pain, or an inflammatory disease, such as, e.g., multiple sclerosis, rheumatoid arthritis or endometriosis.

EP300/CREBBP INHIBITOR

The present invention provides a compound having excellent histone acetyltransferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q1, ring Q2, R1, R2, R3 and R4 respectively have the same meanings as defined in the specification.

AMIDE DERIVATIVES COMPRISING HETEROCYCLOALKYL RING

PROBLEM TO BE SOLVED: To provide compounds or pharmacologically acceptable salts thereof that have excellent EP300 and/or CREBBP histone acetyltransferase inhibitory activity. SOLUTION: The invention provides compounds represented by the formula (1) in the figure or pharmacologically acceptable salts thereof. (In the formula (1), ring Q1, ring Q2, ring Q3, X and L are as defined in the specification.) SELECTED DRAWING: None COPYRIGHT: (C)2020,JPO&INPIT

Synthesis of p-aminobenzoic acid diamides based on 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxylic acid and [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine

Reaction of 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxyl chloride with anesthesin followed by hydrolysis of the formed ester has afforded 4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonylamino]benzoic acid. The acid chloride has been used for acyl

NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF

Compounds of Formula (I) and Formula (II) are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula(I) and Formula (II) have the following structures, where the definitions of the variables are provided herein.