403519-48-2

Upstream product

• 403519-46-0 ethyl 3-methyl-3-(2-methoxy-5-methylphenyl)pent-4-enoate 
• 403519-45-9 E-3-(2-methoxy-5-methylphenyl)but-2-en-1-ol 
• 433732-64-0 ethyl E-3-(2-methoxy-5-methylphenyl)but-2-enoate 
• 20628-07-3 2-acetyl-4-methylanisole 
• 403519-47-1 ethyl 2-allyl-3-(2-methoxy-5-methylphenyl)-3-methylpent-4-enoate 

Relevant academic research and scientific papers

An RCM based approach to (±)-herbertene-l, 14-diol and (±)-tochuinyl acetates

A sequence comprising of Johnson's ortho ester Claisen rearrangement, alkylation and RCM reactions has been developed for the synthesis of cyclopentenes containing vicinal quaternary carbon atoms. The versatility of the sequence has been demonstrated by the efficient total synthesis of sesquiterpenes tochuinyl acetates and herbertene-1,14-diol.

A simple, ring-closing metathesis reaction based approach to (±)-1,14-herbertenediol and (±)-11-epi-herbertenolide

A total synthesis of 1,14-herbertenediol via 11-epi-herbertenolide, and a formal total synthesis of tochuinyl acetate and dihydrotochuinyl acetate, employing a ring-closing metathesis reaction based methodology, are described.