40352-56-5

Upstream product

• 102-09-0 bis(phenyl) carbonate 
• 123-11-5 4-methoxy-benzaldehyde 
• 119-52-8 4,4'-dimethoxybenzoin 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 66851-62-5 (S)-2-[4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-propionic acid 
• 66851-64-7 (S)-2-[4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-4-methyl-pentanoic acid 
• 66851-63-6 (S)-2-[4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-3-phenyl-propionic acid 
• 66851-61-4 [4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-acetic acid 

Relevant academic research and scientific papers

Electrochemical Synthesis and X-Ray Molecular Structure of 2-Arylimino-4,5-Diaryl-1,3-Dioxoles

Selective cathodic reduction of diaryl-1,2-diketones in the presence of N-arylcarbonimidoyl dichlorides leads to 2-arylimino-4,5-diaryl-1,3-dioxoles, a little known class of heterocycle, in almost quantitative yields.NMR spectra of these compounds show a

Direct Synthesis of Vinylene Carbonates from Aromatic Aldehydes**

Substituted vinylene carbonates were directly prepared from aromatic aldehydes following a one-pot Benzoin condensation/transcarbonation sequence under solvent-free conditions. The combination of a N-phenyl substituted triazolium salt NHC precursor and 4-dimethylaminopyridine (DMAP) was found essential to reach high yield and selectivity. The reaction scope was investigated with a range of aromatic aldehydes and the corresponding vinylene carbonates were obtained with 32–86 % isolated yields (14 examples).

Organocatalytic Synthesis of Substituted Vinylene Carbonates

The organocatalytic synthesis of substituted vinylene carbonates from benzoins and acyloins was studied using diphenyl carbonate as a carbonyl source. A range of N-Heterocyclic Carbene (NHC) precursors were screened and it was found that imidazolium salts were the most active for this transformation. The reaction occurs at 90 °C under solvent-free conditions. A wide range of substituted vinylene carbonates (symmetrical and unsymmetrical, aromatic or aliphatic), including some derived from natural products, were prepared with 20–99% isolated yields (24 examples). The reaction was also developed using thermomorphic polyethylene-supported organocatalysts as recoverable and recyclable species. The use of such species facilitates the workup and allows the synthesis of vinylene carbonates on the preparative scale (>30 g after 5 runs). (Figure presented.).

A convenient and safe synthesis of 4,5-disubstituted-2-oxo-1,3-dioxolenes

Employing bis(trichloromethyl)carbonate (BTC), a safe and crystalline substitute of phosgene, 4,5-disubstituted-2-oxo-1,3-dioxolenes 3 have been synthesized by cyclocarbonylation of α-hydroxyketones 1 in 47-67% yield.