77112-05-1

Basic information

• Product Name: Boc-Ser(Bzl)-Tyr(Bzl)-Gly-Leu-OBzl
• Synonyms: Boc-Ser(Bzl)-Tyr(Bzl)-Gly-Leu-OBzl
• CAS NO: 77112-05-1
• Molecular Weight: 808.972
• Mol File: 77112-05-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Boc-Ser(Bzl)-Tyr(Bzl)-Gly-Leu-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Ser(Bzl)-Tyr(Bzl)-Gly-Leu-OBzl(77112-05-1)
• EPA Substance Registry System: Boc-Ser(Bzl)-Tyr(Bzl)-Gly-Leu-OBzl(77112-05-1)

Safety Data

• Hazardous Substances Data: 77112-05-1(Hazardous Substances Data)

Upstream product

• 50715-56-5 Boc-Ser(Bzl)-Tyr(Bzl)-Gly-OEt 
• 100039-27-8 Tyr(Bzl)-Gly-OEt hydrochloride 
• 40356-35-2 BOC-Tyr(OBzl)-Gly-OEt 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 1738-69-8 L-Leucine benzyl ester 
• 50715-57-6 Boc-Ser(Bzl)-Tyr(Bzl)-Glu-OH 

Downstream Products

• 54905-47-4 pGlu-His-Trp-Ser-Tyr-Gly-Leu 
• 84636-31-7 C₆₃H₇₀N₁₀O₁₁ 
• 84636-30-6 Ser(Bzl)-Tyr(Bzl)-Gly-Leu-OBzl 

Relevant articles and documents

An Approach to the Elucidation of Metabolic Breakdown Products of the Luteinizing Hormone-Releasing Hormone

Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGlu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).We have synthesized fragments 2-10 and successfully separated all ten metabolites and LH-RH by high-performance liquid chromatography (HPLC) with μBondapak C18 column.In a test of viability of the method, cochromatography of fragments 1-10 and LH-RH with the products of chymotryptic digestion of tritiated LH-RH showed radioactive peaks corresponding to the expected products, fragments 3 and 5.Analysis of the products of incubation of a rat kidney homogenate supernatant with LH-RH showed fragments 1-4 and LH-RH.The finding of breakdown at position 4 uncovers a new site of LH-RH breakdown and points the way to the design of potential LH-RH antagonists and agonists where the 4 position would be substituted with unnatural amino acids to prevent breakdown.