40358-38-1

Basic information

• Product Name: 2,3,4,5-Tetrahydro-2,2,4-trimethyl-1H-1,5-benzodiazepine
• Synonyms: 2,3,4,5-Tetrahydro-2,2,4-trimethyl-1H-1,5-benzodiazepine
• CAS NO: 40358-38-1
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.28
• Mol File: 40358-38-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,3,4,5-Tetrahydro-2,2,4-trimethyl-1H-1,5-benzodiazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,5-Tetrahydro-2,2,4-trimethyl-1H-1,5-benzodiazepine(40358-38-1)
• EPA Substance Registry System: 2,3,4,5-Tetrahydro-2,2,4-trimethyl-1H-1,5-benzodiazepine(40358-38-1)

Safety Data

• Hazardous Substances Data: 40358-38-1(Hazardous Substances Data)

Upstream product

• 24107-34-4 2,2,4-trimethyl-2,3-dihydro-1H-1,5-benzodiazepine 
• 95-54-5 1,2-diamino-benzene 
• 141-79-7 4-methyl-pent-3-en-2-one 
• 615-28-1 o-phenylenediamine dihydrochloride 
• 67-64-1 acetone 

Downstream Products

• 136320-02-0 (11S,12R)-12-(3,4-Dichloro-phenyl)-9,9,11-trimethyl-1,8-diaza-tricyclo[6.3.1.0^2,7]dodeca-2⁽⁷⁾,3,5-triene 
• 136320-03-1 (11S,12R)-9,9,11-Trimethyl-12-(3-nitro-phenyl)-1,8-diaza-tricyclo[6.3.1.0^2,7]dodeca-2⁽⁷⁾,3,5-triene 

Relevant articles and documents

Synthesis and antiproliferative activity in vitro of novel 1,5-benzodiazepines. Part II

The reaction of 2,2,4-trimethyl-1H-2,3-dihydro-1,5-benzodiazepine (1) with cinnamoyl chloride leading to the formation of 1-cinnamoyl derivative 2 is described. Two novel benzodiazepines, 2,2,4-trimethyl-1H-2,3,4,5-tetrahydro-1,5-benzodiazepine (3) and 1-

First pre-functionalised polymeric aromatic framework from mononitrotetrakis(iodophenyl)methane and its applications

Starting from mononitrotetrakis(iodophenyl)methane as monomer, we report the preparation of the first pre-functionalised porous aromatic frameworks (PAFs) and their application as supports for organometallic catalysts. Neutral coordinate imino-pyridine Schiff base (PAF-NPy) or chiral bis-amino (PAF-NPro) ligands were obtained by post-synthetic treatment of PAF-NH2 and treated with copper(I) or rhodium(I) to yield the corresponding supported transition-metal catalysts. The as-prepared PAF-NN-M catalysts exhibited activity and selectivity similar to that of the corresponding homogeneous catalysts and were easily removed from reaction media and recycled without loss of activity or selectivity. New copper catalysts: The preparation of pre-functionalised porous aromatic frameworks (PAFs) and their application as supports for organometallic catalysts (see figure) is reported for the first time.

STEREOSELECTIVE BRIDGING OF TETRAHYDRO-1,5-BENZODIAZEPINES

A reaction of tetrahydro-1,5-benzodiazepines with aromatic aldehydes which yields the hitherto unknown 1,5-methanotetrahydro-1,5-benzodiazepines as a single stereoisomer is described.The stereochemistry of the products is established using proton nmr spec