24107-34-4

Usage

Chemical Class

Benzodiazepines A class of psychoactive drugs commonly used for their sedative, hypnotic, and anxiolytic properties.

Molecular Structure

1,4-Benzodiazepine derivative 2,2,4-TRIMETHYL-2,3-DIHYDRO-1H-1,5-BENZODIAZEPINE is derived from the 1,4-benzodiazepine structure, which is the basis for many benzodiazepine drugs.

Methyl Groups

Three methyl groups attached The compound has three methyl groups attached to the 2, 2, and 4 positions of the molecule, which may influence its potency and duration of action.

Central Nervous System Depressant

Anxiolytic, sedative, and hypnotic effects 2,2,4-Trimethyl-2,3-dihydro-1H-1,5-benzodiazepine acts as a central nervous system depressant, helping to alleviate anxiety, promote relaxation, and induce sleep.

Medical Uses

Treatment of anxiety disorders, insomnia, and epilepsy This specific benzodiazepine is prescribed to treat various conditions, including anxiety disorders, sleep disturbances, and epilepsy, due to its calming and seizure-preventing effects.

Potential for Abuse and Dependence

Risk of misuse and addiction Like other benzodiazepines, 2,2,4-Trimethyl-2,3-dihydro-1H-1,5-benzodiazepine carries a potential for abuse and dependence, which should be considered when prescribing and using the medication.

Tolerance and Withdrawal Symptoms

Long-term use may lead to tolerance and withdrawal Prolonged use of this benzodiazepine can result in the development of tolerance, requiring higher doses for the same effect, and may also cause withdrawal symptoms if discontinued abruptly.

InChI:InChI=1/C12H16N2/c1-9-8-12(2,3)14-11-7-5-4-6-10(11)13-9/h4-7,14H,8H2,1-3H3

Upstream product

• 98-86-2 acetophenone 
• 95-54-5 1,2-diamino-benzene 
• 67-64-1 acetone 
• 141-79-7 4-methyl-pent-3-en-2-one 
• 528-29-0 1,2-Dinitrobenzene 
• 615-28-1 o-phenylenediamine dihydrochloride 

Downstream Products

• 108324-92-1 5,6-dihydro-1-hydroxy-5,5-dimethyl-1-phenyl-3-phenylamino-1H-pyrrolo<1,2-a><1,5>-benzodiazepin-2<4H>-one 
• 106366-69-2 3-Ethoxycarbonyl-3a,5,5-trimethyl-1-phenyl-3a,4,5,6-tetrahydro-3H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepine 
• 127535-65-3 3a,5,5-Trimethyl-1-phenyl-3a,4,5,6-tetrahydro-3-oxa-2,6,10b-triaza-benzo[e]azulene 
• 102651-36-5 2,3-dihydro-2,2-dimethyl-4-<(E)-2-phenylvinyl>-1,5-benzodiazepine 
• 106366-67-0 3a,5,5-Trimethyl-1,3-diphenyl-3a,4,5,6-tetrahydro-3H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepine 
• 1234803-58-7 2,2,4-trimethyl-1-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-2,3-dihydro-1,5-benzodiazepine 
• 14525-98-5 2-[(2-aminophenylamino)methylene]malonic acid diethyl ester 
• 136320-03-1 (11S,12R)-9,9,11-Trimethyl-12-(3-nitro-phenyl)-1,8-diaza-tricyclo[6.3.1.0^2,7]dodeca-2⁽⁷⁾,3,5-triene 
• 136320-02-0 (11S,12R)-12-(3,4-Dichloro-phenyl)-9,9,11-trimethyl-1,8-diaza-tricyclo[6.3.1.0^2,7]dodeca-2⁽⁷⁾,3,5-triene 
• 102651-36-5 4-(2-phenylvinyl)-2,2-dimethyl-1H-1,5-benzodiazepine 
• 40358-38-1 2,3,4,5-tetrahydro-2,2,4-trimethyl-1H-benzo[b][1,4]diazepine 

Relevant academic research and scientific papers

Growth-modulating agents for the synthesis of Al-MOF-type materials based on assembled 1D structural subdomains

Novel aluminium MOF-type materials structured by 1D subdomains, such as organic-inorganic nanoribbons, were synthesized by modifying the conditions of solvothermal synthesis and the nature of the solvents in the presence of aryl monocarboxylate linkers wi

Metal-organic frameworks as efficient catalytic systems for the synthesis of 1,5-benzodiazepines from 1,2-phenylenediamine and ketones

Benzodiazepines and their derivatives are a very important class of nitrogen-containing heterocyclic compounds with biological activity that are widely used in medicine. In this study, we demonstrated synthesis of 1,5-benzodiazepines from 1,2-phenylenedia

1,5-benzoxazepines vs 1,5-benzodiazepines. one-pot microwave-assisted synthesis and evaluation for antioxidant activity and lipid peroxidation inhibition

Amino-1,5-benzoxazepines 2 and 5 and hydroxyl-1,5-benzodiazepines 3 and 6 have been synthesized in one-pot solvent-free conditions from 2,3-diaminophenol and ketones through microwave assisted acid catalysis, the benzoxazepine/ benzodiazepine ratio depend

Multisite solid catalyst for cascade reactions: The direct synthesis of benzodiazepines from nitro compounds

Substituted 1,5-benzodiazepines are selectively synthesized in one pot from substituted nitroaromatics and ketones. The reaction is performed in the presence of hydrogen and in the absence of solvent by using a bifunctional solid catalyst with a chemoselective hydrogenation functional group capable of reducing the nitro group to a diamino group and an acid functional group, which catalyzes the cyclocondensation of the amino group with the ketone.

NEW SYNTHESIS OF DIHYDRO- AND TETRAHYDRO-1,5-BENZODIAZEPINES BY REDUCTIVE CONDENSATION OF O-PHENYLENEDIAMINE AND KETONES IN THE PRESENCE OF SODIUM BOROHYDRIDE

Dihydro- and tetrahydro-benzodiazepines have been synthesized from o-phenylenediamine dihydrochloride and aliphatic ketones in the presence od sodium borohydride.