403647-92-7Relevant articles and documents
HIV-1 replication inhibitors of the styrylquinoline class: Incorporation of a masked diketo acid pharmacophore
Zouhiri, Fatima,Desma?le, Didier,D'Angelo, Jean,Ourevitch, Michèle,Mouscadet, Jean-Fran?ois,Leh, Hervé,Le Bret, Marc
, p. 8189 - 8192 (2001)
A novel variant of HIV-1 replication inhibitors of the styrylquinoline class, bearing an α-keto acid appendage at C-7, has been synthesized. Though completely inactive in in vitro experiments against HIV-1 integrase, this compound exhibited a significant antiviral activity (IC50 = 10 μM).