403731-50-0

Upstream product

• 98-86-2 acetophenone 
• 62837-59-6 1,2-dimethyl-1-phenyl-1-propanol 
• 769-57-3 α,β,β-trimethylstyrene 

Downstream Products

• 403731-45-3 3,3-dimethyl-4-hydroxymethyl-4-phenyl-1,2-dioxetane 

Relevant academic research and scientific papers

Spiroiminodihydantoin is a major product in the photooxidation of 2′-deoxyguanosine by the triplet states and oxyl radicals generated from hydroxyacetophenone photolysis and dioxetane thermolysis

(formula presented) Photolysis of hydroxyacetophenone and thermolysis of the corresponding dioxetane afford spiroiminodihydantoin rather than 4,8-dihydro-4-hydroxy-8-oxo-2′-deoxyguanosine (4-HO-8-oxodG) through the oxidation of 2′-deoxyguanosine (dG) by triplet-excited hydroxyacetophenone and the peroxyl radicals derived thereof by α cleavage and subsequent oxygen trapping. The structure of the spiroiminodihydantoin is assigned by the SELINQUATE NMR technique, which unequivocally establishes the spirocyclic connectivity.