403796-40-7

Upstream product

• 129694-52-6 ethyl (Z)-N-(2-amino-1,2-dicyanovinyl)formimidate 
• 89-99-6 2-fluorobenzylamine 
• 358657-89-3 Ethyl (Z)-N-(2-amino-1,2-dicyanovinyl)formimidate 

Downstream Products

• 412050-53-4 5-amino-N¹-(2-fluorobenzyl)-3H-imidazo[4,5-b]pyridine-6-carbonitrile 
• 412050-51-2 5-amino-1-(2-fluoro-benzyl)-1H-imidazole-4-carbaldehyde 
• 154909-85-0 5-amino-N¹-(2-fluorobenzyl)-4-cyanoimidazole 
• 403796-48-5 9-(2-fluoro-benzyl)-9H-purine-6-carbonitrile 

Relevant academic research and scientific papers

Synthesis of 1-substituted 5-aminoimidazole-4-carbaldehydes and 8-amino-1-(2-fluorobenzyl)imidazo[4′,5′:5,6]pyrido[2,3-d] pyrimidine

The syntheses of a number of 1-substituted 5-aminoimidazole-4-carbaldehydes 3, by the reduction of the corresponding 5-amino-4-cyanoimidazole derivatives is reported using LiAlH(OEt)3, prepared in situ from LiAlH4 and ethyl acetate. The compounds of type 1 are useful intermediates for the synthesis of elongated adenine derivatives.

Facile synthesis of 6-cyano-9-substituted-9H-purines and their ring expansion to 8-(arylamino)-4-imino-3-methylpyrimidino-[5,4-d]pyrimidines

6-Cyano-9-substituted-9H-purines were prepared in a high yielding, one-step process by refluxing triethyl orthoformate or triethyl orthopropionate with the corresponding (Z)-N1-(aryl- or benzyl)-N2-(2-amino-1,2-dicyanovinyl)formamidi