358657-89-3Relevant academic research and scientific papers
2-AMIDO-6-AMINO-8-OXOPURINE DERIVATIVES AS TOLL-LIKE RECEPTOR MODULATORS FOR THE TREATMENT OF CANCER AND VIRAL INFECTIONS, SUCH AS HEPATITIS C
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Page/Page column 59, (2010/11/24)
This invention relates to purine derivatives, to processes for their preparation, to compositions containing them and to their use. The present invention provides compounds of formula (I) wherein R1, R2, R3, R9, R9a and Y are defined in the description. More particularly, the present invention relates to the use of purine derivatives in the treatment of a variety of viral infections and immune or inflammatory disorders, including those in which the modulation, in particular agonism, of Toll-Like Receptors (TLRs) is implicated. Accordingly, the compounds of the invention are useful in the treatment of infectious disease such as Hepatitis (e.g. HCV, HBV), genetically related viral infections, inflammatory diseases such as asthma and arthritis, and cancer.
An improved synthesis of 9-benzyladenine: A model for adenosine and its analogues
Sun,Hosmane
, p. 549 - 554 (2007/10/03)
An improved synthesis of 9-benzyladenine (I), a model for a variety of biologically and therapeutically significant adenine nucleosides, has been reported. The target compound was synthesized by condensation of 1-benzyl-4-cyano-5-methoxymethyleneiminoimidazole (14) with guanidine. Compound 14 was prepared from 5-amino-1-benzyl-4-cyanoimidazole (5), which in turn was prepared by reaction of benzylamine with ethyl (Z)-N-(2-amino-1,2-dicyanovinyl) formimidate (13). The latter was synthesized by reaction of diaminomaleonitrile (6) with triethyl orthoformate.
