4042-43-7

Basic information

• Product Name: (4R)-4-Methyl-2-oxazolidinone
• Synonyms: (4R)-4-Methyl-2-oxazolidinone
• CAS NO: 4042-43-7
• Molecular Formula: C₄H₇NO₂
• Molecular Weight: 101.10388
• Mol File: 4042-43-7.mol
• Article Data: 11

Chemical Properties

• Melting Point: 45.9 °C
• Boiling Point: 302.6 °C at 760 mmHg
• Flash Point: 136.8 °C
• Appearance: /
• Density: 1.095 g/cm³
• Storage Temp.: 2-8°C
• PKA: 12.84±0.40(Predicted)
• CAS DataBase Reference: (4R)-4-Methyl-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-4-Methyl-2-oxazolidinone(4042-43-7)
• EPA Substance Registry System: (4R)-4-Methyl-2-oxazolidinone(4042-43-7)

Safety Data

• Hazardous Substances Data: 4042-43-7(Hazardous Substances Data)

Usage

General Description

"(4R)-4-Methyl-2-oxazolidinone is an organic compound characterized by its oxazolidinone class. Classified within the group of azolidines, which are saturated compounds containing a 1-azolidine moiety, it is a chiral auxiliary used in organic synthesis to set up a stereogenic center. It is often used in the preparation of drugs, particularly antibiotics, as its 2-oxazolidinone substructure can be found in several medications. Its chiral nature makes it useful in the synthesis of pharmaceuticals as it allows for the creation of chirally pure compounds. The compound has a molecular formula of C4H7NO2.

Upstream product

• 35320-23-1 (R)-2-aminopropan-1-ol 
• 105-58-8 Diethyl carbonate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 28875-17-4 (S)-N-(tert-butoxycarbonyl)alanine methyl ester 
• 75-44-5 phosgene 
• 24406-16-4 lithium di-n-butylcuprate 
• 154669-49-5 [(S)-2-oxooxazolidin-4-yl]methyl-4-methylbenzenesulfonate 

Downstream Products

• 1178576-56-1 C₁₂H₁₁NO₂ 
• 1178576-57-2 (R)-3-methyl-5-oxo-2,3-dihydro-5H-oxazolo[3,2-b]isoquinoline-10-carboxylic acid ethyl ester 
• 1178576-55-0 C₁₅H₁₇NO₅ 
• 1178576-60-7 [4,5-dimethoxy-2-(R-4-methyl-2-oxo-oxazolidine-3-carbonyl)-phenyl]-acetic acid ethyl ester 
• 1215126-67-2 (4R)-3-(3-Aminophenyl)-4-methyl-1,3-oxazolidin-2-one 
• 1223431-88-6 methyl (R)-2-methoxy-4-(4-methyl-2-oxooxazolidin-3-yl)benzoate 
• 1160723-61-4 (R)-4-methyl-3-(2-phenylethynyl)oxazolidin-2-one 
• 442161-45-7 3-{4-[2-(3-chloro-phenylamino)-pyrimidin-4-yl]-pyridin-2-yl}-4-methyl-oxazolidin-2-one 
• 904848-89-1 (E)-(R)-N-[(3S)-2,3-diphenylbut-1-enyl]-4-methyloxazolidin-2-one 
• 457602-61-8 (Z,4R,3'S)-3-(2',3'-diphenylbut-1'-enyl)-4-methyloxazolidin-2-one 
• 572922-96-4 (R)-4-Methyl-3-(4-trifluoromethyl-phenyl)-oxazolidin-2-one 

Relevant articles and documents

BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE

Described herein are benzoxazepin oxazolidinone compounds with phosphoinositide- 3 kinase (PI3K) modulation activity or function having the Formula (I) structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such PI3K modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon PI3K dysregulation.

Chemoselective room temperature E1cB N-N cleavage of oxazolidinone hydrazides from enantioselective aldehyde α-hydrazination: Synthesis of (+)-1,4-dideoxyallonojirimycin

Room temperature E1cB N-N cleavage of oxazolidinone hydrazides via N-alkylation with diethyl bromomalonate and potassium or caesium carbonate as base in acetonitrile is presented. The new method has a much improved chemoselectivity, which is illustrated by a concise total synthesis of the piperidine iminosugar (+)-1,4-dideoxyallonojirimycin.

BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 RECEPTOR AGONISTS.

This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds include those according to formula 1, or a salt thereof, wherein Q, R1 , R2, R3 and R4 are as defined herein.