404369-20-6Relevant articles and documents
Efficient synthesis of 3-hydroxyprolines and 3-hydroxyprolinols from sugars
Lee, Jin Hwan,Kang, Jae Eun,Yang, Min Suk,Kang, Kyu Young,Park, Ki Hun
, p. 10071 - 10076 (2007/10/03)
trans-3-Hydroxy-L-proline 1, trans-3-hydroxy-L-prolinol 2, cis-3-hydroxy-D-proline 3, and cis-3-hydroxy-D-prolinol 4 have been prepared in enantiomerically pure form with chirospecific manner. Key intermediates, 2-amino-3-hydroxy-4-pentenoate 9 and 17, were obtained from D-glucono-δ-lactone and L-gulonic acid γ-lactone via a simultaneous dealkoxyhalogenation.