404387-08-2

Upstream product

• 20877-88-7 2-(aminomethyl)-N-methylaniline 
• 148580-01-2 (2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-[2-nitro-4-(4-nitro-phenoxycarbonyloxymethyl)-phenoxy]-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 1885-29-6 anthranilic acid nitrile 
• 17583-40-3 2-methylaminobenzonitrile 

Downstream Products

• 404387-10-6 (2S,3S,4S,5R,6S)-6-(4-{2-[(4,5-Dimethoxy-2-nitro-benzyloxycarbonyl)-methyl-amino]-benzylcarbamoyloxymethyl}-2-nitro-phenoxy)-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 404387-11-7 (2S,3S,4S,5R,6S)-6-(4-{2-[(4,5-Dimethoxy-2-nitro-benzyloxycarbonyl)-methyl-amino]-benzylcarbamoyloxymethyl}-2-nitro-phenoxy)-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid 
• 404387-09-3 (2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-(4-{2-[(4,5-dimethoxy-2-nitro-benzyloxycarbonyl)-methyl-amino]-benzylcarbamoyloxymethyl}-2-nitro-phenoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and β-glucuronidase mediated cleavage of an alcohol prodrug incorporating a double spacer moiety

An alcohol prodrug has been prepared by incorporation of two spacer groups between the trigger (glucuronic acid) and nitroveratryl alcohol, used as a model. Release of the later has been observed after hydrolysis of the glycoside by β-glucuronidase. Such prodrugs may find application in ADEPT or PMT potocols in cancer chemotherapy.