4044-54-6

Usage

Uses

Used in Pharmaceutical Synthesis:
2,3-dihydro-1H-indene-4-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique chemical structure allows for the development of new drugs with potential therapeutic benefits.
Used in Antiviral Drug Development:
2,3-dihydro-1H-indene-4-carboxylic acid is used as an inhibitor of hepatitis C virus replication. Its antiviral properties make it a promising candidate for the development of new antiviral drugs to combat hepatitis C and potentially other viral infections.
Used in Cancer Treatment:
As a potential cytochrome P450 inhibitor, 2,3-dihydro-1H-indene-4-carboxylic acid may be used in the treatment of cancer and other diseases. Its ability to modulate the activity of cytochrome P450 enzymes could lead to the development of novel therapeutic strategies for cancer management.

Upstream product

• 15115-61-4 4-chloro-indan 
• 77635-15-5 1-Indanol-7-carboxylic acid 
• 776-79-4 2-(2-carboxyethyl)benzoic acid 
• 496-11-7 INDANE 
• 65898-33-1 (2,3-dihydro-1H-inden-4-yl)methanol 
• 75934-00-8 2-Allyl-6-(carbomethoxy)anisole 
• 75934-01-9 2-Methoxy-3-allylbenzoic Acid 
• 6282-42-4 methyl 2-allyloxybenzoate 
• 38997-95-4 5-(tert-butyl)-2,3-dihydro-1H-indene 
• 38997-96-5 4-Acetyl-6-tert-butylindan 
• 56461-20-2 1-oxoindane-4-carboxylic acid 
• 38997-97-6 1-(2,3-dihydro-1H-inden-4-yl)ethanone 
• 5020-63-3 6-tert-Butylindan-4-carbonsaeure 
• 51932-70-8 indane-4-carboxaldehyde 

Downstream Products

• 32202-61-2 4-aminoindan 
• 86031-42-7 4-Indancarbonsaeuremethylester 
• 5385-28-4 indan-4-yl-phenyl ketone 
• 201486-99-9 (+/-)-Hydroxy-phenyl-(indanyl-⁽⁴⁾)-methan 
• 55934-10-6 methyl 1-oxo-2,3-dihydro-1H-indene-4-carboxylate 
• 5020-62-2 (4-indanyl)acetic acid 

Relevant academic research and scientific papers

Synthesis based on Cyclohexadienes. Part-271. Synthesis of Functionalized Tricyclo[5.2.2.01,5]undecanes

A new methodology for the construction of tricyclo[5.2.2.01,5]undecanes is described from indane-4-carboxylic acids. Birch reduction of indane-4-carboxylic acids followed by conjugation and cycloaddition with α-ehloroacrylonitrile and hydrolysi

Photochemically generated bicyclic ortho-quinodimethanes: Photo- enolization of bicyclic aldehydes and ketones

A photoenolization route to bicyclic ortho-quinodimethanes was investigated. Bicyclic photoenols were trapped in an intermolecular fashion with various dienophiles for the first time. All ortho-quinodimethane precursors were prepared via a selective route commencing with 1-indanol, α- tetralol and 1-benzosuberone. Irradiation afforded the E-photoenols exclusively which were trapped with equal efficiency except that derived from indane-4-carboxaldehyde. This low efficiency has been ascribed to rapid auto- oxidation of the aldehyde to carboxylic acid. The facial selectivity of the reaction between the photoenol from benzosuberan-9-carboxaldehyde and dimethyl fumarate was much lower when compared to the other aldehydes in this study. A distorted diene caused by the presence of the seven membered ring explains these results.

Aromatic Spiranes, XXII [1]: Preparation of Cyclopenteno-4,5-indan-1-one and 2-Carbomethoxy- and 4-Chloromethyl-indane as Synthones for the Syntheses of Anellated 2,2′-Spirobiindanone

The title compounds were prepared as follows: tert.-butyl-indane (10) was formylated to give a 72:28 mixture of the aldehydes 23a and 23b which were submitted to a Knoevenagel-Doebner condensation to afford the cinnamonic acids 24. From the mixture, the p