51932-70-8

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indene-4-carboxaldehyde, 2,3-dihydro(9CI) is used as a reagent for the preparation of sulfonylurea compounds. These compounds are known for their ability to modulate NLRP (NOD-like receptor family, pyrin domain containing) activity, which plays a crucial role in the regulation of inflammation and immune responses. By targeting NLRP activity, sulfonylurea compounds can be employed in the treatment of various conditions, such as autoimmune disorders and chronic inflammatory diseases.

Upstream product

• 201230-82-2 carbon monoxide 
• 496-11-7 INDANE 
• 116451-83-3 (2E,8E)-deca-2,8-diene-1,10-dial 
• 4885-02-3 Dichloromethyl methyl ether 

Downstream Products

• 4044-54-6 2,3-dihydro-1H-indene-4-carboxylic acid 
• 201486-99-9 (+/-)-Hydroxy-phenyl-(indanyl-⁽⁴⁾)-methan 
• 5020-62-2 (4-indanyl)acetic acid 
• 5385-28-4 indan-4-yl-phenyl ketone 

Relevant academic research and scientific papers

Synthesis of aromatic aldehydes by organocatalytic [4+2] and [3+3] cycloaddition of α,β-unsaturated aldehydes

Organocatalytic inter- and intramolecular [4+2] and [3+3] cycloadditions of α,β-unsaturated aldehydes to give polysubstituted aromatic aldehydes are described. High periselectivity for the cycloadditions, with catalyst effects exerted by l-proline and pyrrolidine-HOAc, as well as cocatalyst, additive effects, has been observed.

Formylation of Aromatic Compounds with CO in HSO3F-SbF5 under Atmospheric Pressure

The formylation of aromatic compounds such as benzene, toluene, xylenes, mesitylene, indan, tetralin, fluorobenzene, chlorobenzene, and bromobenzene was carried out in HSO3F-SbF5 under atmospheric CO pressure at 0 deg C.In HSO3F-SbF5, both formylation and sulfonation took place to give formyl and sulfonyl compounds.In the case of alkylbenzenes, including toluene, xylenes, mesitylene, and tetralin, formylalkylbenzenesulfonyl fluorides, new compounds, were obtained by a one-pot reaction as well as alkylbenzaldehydes, alkylbenzenesulfonyl fluorides, and bis(alkylphenyl) sulfones.The direct introduction of a formyl and sulfonyl group was achieved in alkylbenzenes.The reaction path of the new compounds is a two-step reaction comprised of formylation as the first step and sulfonation as the second step.The product composition was strongly dependent on the acid strength of the HSO3F-SbF5 systems.The formyl compounds became predominant with increasing acidity of the HSO3F-SbF5 system.On the other hand, only sulfonyl compounds were produced when the acidity of the HSO3F-SbF5 system was low.

Optically Active Spiranes, XI: Syntheses of Optically Active Mono to Heptasubstituted 5-Methyl and Ethyl-2,2'-Spirobiindanes and Related Naphthalene Derivatives of Known Chirality and Enantiomeric Purity

Starting from optically active 5,5'-dimethyl, diethyl, and 5-ethyl-5'-methyl-2,2'-spirobiindane as well as from 5'-ethyl-spirobiindane-5-carboxylic ester of known enantiomeric purity and configuration 75 mono to polysubstituted 2,2'-spirobiindanes have been prepared.Amongst these are several compounds with rings anellated in the 6,7 (and 6',7') positions, especially a spirohydrocarbon 4x with orthogonal naphthalene units the circular dichroism of which is reported and discussed.Several mono and disubstituted 5-methyl and ethylindanes (1, 2) have been prepared as models for synthetic transformations in the spirobiindane series.From the molar rotations of symmetrically diacylated 5,5'-dimethyl and diethyl spirobiindanes (4a, 7b, 7c) empirical ligand parameters λ for acetyl and methoxycarbonyl were determined which gave much better results in the calculation of the rotations of appropriate spirobiindanes (with the "shortened polynomal Ansatz") than the λ-values deduced previously from 5,5'-disubstituted spirobiindanes.The significance of these results is briefly discussed. - Keywords: Chirality function; Circular dichroism; Ligand parameters; 5-Methyl and ethylindanes; 1H-NMR spectra