404580-71-8

Upstream product

• 105-13-5 4-Methoxybenzyl alcohol 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 866124-70-1 p-methoxybenzyloxydiphenylphosphine 
• 937184-70-8 2-(4-methoxybenzyloxy)-4-methylquinoline 
• 333-27-7 methyl trifluoromethanesulfonate 
• 2746-25-0 p-Methoxybenzyl bromide 
• 93021-93-3 1-methoxy-4-((3-phenylprop-2-yn-1-yl)oxy)benzene 

Downstream Products

• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 

Relevant academic research and scientific papers

Combining visible light catalysis and transfer hydrogenation for in situ efficient and selective semihydrogenation of alkynes under ambient conditions

By combining visible light catalysis and transfer hydrogenation, we are able to convert a series of alkynes to their corresponding alkenes in high chemical yields. Then the visible light catalytic transfer hydrogenation reaction can couple photoisomerization to produce E-alkenes or Z-alkenes exclusively depending on the aryl or alkyl substituted alkynes.

Intramolecular alkene electrophilic bromination initiated ipso -bromocyclization for the synthesis of functionalized azaspirocyclohexadienones

Intramolecular alkene electrophilic bromination initiated dearomative cyclization has been realized in the presence of DBDMH to provide functionalized azaspirocyclohexadienones in excellent yields under mild conditions.

An efficient means for generating p-methoxybenzyl (PMB) ethers under mildly acidic conditions

The protection of a wide variety of alcohols as their p-methoxybenzyl ethers can be performed with PMBO-lepidine in the presence of methyl tosylate or, preferably, camphorsulfonic acid. No inorganic promoters are required, thereby facilitating workup and product isolation. Georg Thieme Verlag Stuttgart.

Synthesis of para-methoxybenzyl (PMB) ethers under neutral conditions

2-(4-Methoxybenzyloxy)-4-methylquinoline reacts with methyl triflate in the presence of alcohols to generate a neutral organic salt that transfers the para-methoxybenzyl (PMB) protecting group onto alcohols in high yield and under mild conditions. The Royal Society of Chemistry.

Efficient methods for the preparation of alkyl-aryl and symmetrical or unsymmetrical dialkyl ethers between alcohols and phenols or two alcohols by oxidation-reduction condensation

Oxidation-reduction condensation via alkoxydiphenylphosphines (diphenylphosphinite esters) (1), generated in situ from chlorodiphenylphosphine (2) and alcohols, 2,6-dimethyl-1,4-benzoquinone (3), and phenols proceeds smoothly to afford alkyl-aryl ethers in good to high yields under neutral conditions. In a similar fashion, a new and efficient method for the preparation of symmetrical or unsymmetrical dialkyl ethers in good to high yields is established via tetrafluoro-1,4-benzoquinone (fluoranil) (4), alcohols, and 1 formed in situ from nBuLi-treated alcohols and 2. This method is applicable also to the etherification of chiral secondary or tertiary alcohols with retention or inversion of configurations. The inverted ethers are afforded by treating chiral alkoxydiphenylphosphines and achiral alcohols, while the reaction of achiral alkoxydiphenylphosphines and chiral alcohols forms retained ethers.

A Convenient Method for the Preparation of Symmetrical or Unsymmetrical Ethers by the Coupling of Two Alcohols via a New Type of Oxidation-reduction Condensation Using Tetrafluoro-1,4-benzoquinone

A new type of oxidation-reduction condensation by using tetrafluoro-1,4-benzoquinone (fluoranil), alcohols and alkoxydiphenylphosphines, in situ formed from nBuLi-treated alcohols and chlorodiphenylphosphine, proceeded smoothly to afford the corresponding symmetrical or unsymmetrical ethers in good to high yields.