40474-00-8

Upstream product

• 40474-01-9 1-methoxy-4-((4-(trifluoromethyl)phenyl)ethynyl)benzene 
• 455-14-1 4-trifluoromethylphenylamine 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 540-38-5 p-Iodophenol 
• 705-31-7 4-trifluoromethylphenylacetylene 
• 400608-34-6 4-tetrahydropyranyloxy-4'-trifluormethyltolan 
• 150508-72-8 trimethyl{[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]ethynyl}silane 
• 99522-34-6 4-[(tetrahydro-2H-pyran-2-yl)oxy]iodobenzene 
• 132312-99-3 1-methoxy-4-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]benzene 
• 40473-97-0 4-Trifluormethyl-4'-methoxy-α,β-dibromstilben 

Relevant academic research and scientific papers

Intermolecular Desymmetrizing Gold-Catalyzed Yne–Yne Reaction of Push–Pull Diarylalkynes

Push–pull diaryl alkynes are dimerized in the presence of a cationic gold catalyst. The polarized structure of the applied starting materials enables the generation of a highly reactive vinyl cation intermediate in an intermolecular reaction. Trapping of the vinyl cation by a nucleophilic attack of the electron-poor aryl unit then leads to the selective formation of highly substituted naphthalenes in a single step and in complete atom economy.

ASCORBATE, VITAMIN K3 AND HYDROXYTOLANS IN THE TREATMENT OF CANCER

The combination of compounds of the hydroxytolan family with ascorbate plus naphthoquinone (Vitamin K3; VK3), or a quinone or semiquinone analogue of VK3, kill tumor cells, inhibit tumor growth and development, and treat cancer in subjects in need thereof.