40484-94-4Relevant academic research and scientific papers
Synthesis of benzofurans from the cyclodehydration of α-phenoxy ketones mediated by Eaton’s reagent
Ma, Lin,Ma, Zhanwei,Zhang, Min,Zhou, Min
, p. 426 - 436 (2020/03/23)
Cyclodehydration of α-phenoxy ketones promoted by Eaton’s reagent (phosphorus pentoxide–methanesulfonic acid) is used to prepare 3-substituted or 2,3-disubstituted benzofurans with moderate to excellent yields under mild conditions. The method provides a facile access to benzofurans from readily available starting materials such as phenols and α-bromo ketones. The reaction is highly efficient, which is attributed to the good reactivity and fluidity of Eaton’s reagent. The reaction can be applied to prepare naphthofurans, furanocoumarins, benzothiophenes, and benzopyrans.
Titanium tetrachloride promoted cyclodehydration of aryloxyketones: Facile synthesis of benzofurans and naphthofurans with high regioselectivity
Zhang, Qiu,Luo, Juan,Wang, Bingqiao,Xiao, Xiaoqin,Gan, Zongjie,Tang, Qiang
, p. 1337 - 1340 (2019/04/16)
An efficient and facile method for the synthesis of a broad series of benzofurans and naphthofurans is described. The direct intramolecular cyclodehydration of aryloxyketones in the presence of titanium tetrachloride affords the corresponding benzofurans and naphthofurans with good regioselectivity and yields.
Method for synthesizing benzofuran derivative by taking alpha-phenoxy-ketone as raw material
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Paragraph 0037; 0038; 0039; 0040, (2019/04/26)
The invention discloses a method for synthesizing a benzofuran derivative by taking alpha-phenoxy-ketone as a raw material. Under shielding of inert gas, the alpha-phenoxy-ketone is dissolved in dry dichloromethane, then a mixed solution of TiCl4 and dichloromethane is dropwise added slowly, and after the indoor temperature reaction, the benzofuran derivative after separation and purification is obtained. The method for synthesizing the benzofuran derivative has the advantages that raw materials are easy to obtain, the cost is low, and reaction conditions are mild; operation is simple and easyto control, there are fewer side reactions, and the after-processing is simple; the yield of the derivative is higher, the production cost is greatly reduced, better economic benefits are achieved, and the method is suitable for industrial production.
SYNTHESIS OF BENZOFURANS VIA PALLADIUM-PROMOTED CYCLIZATION OF ORTHO-SUBSTITUTED ARYL ALLYL ETHERS
Larock, Richard C.,Stinn, Dean E.
, p. 4687 - 4690 (2007/10/02)
o-Iodo- or (chloromercurio)aryl allyl ethers undergo facile palladium-promoted cyclization to benzofurans.
